Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

The Dichotomous Roles of Microbial-Modified Bile Acids 7-Oxo-DCA and isoDCA in Intestinal Tumorigenesis

November 15, 2024

[Proceedings of The National Academy of Sciences of The United States of America] Researchers found that although high-fat diet treatment in mice elevated both 7-oxo-deoxycholic acid (7-oxo-DCA) and isoDCA levels, during intestinal tumorigenesis, 7-oxo-DCA levels increased while isoDCA levels decreased.

RNF4 Mediated Degradation of PDHA1 Promotes Colorectal Cancer Metabolism and Metastasis

November 15, 2024

[npj Precision Oncology] The authors investigated the role of RNF4-mediated ubiquitination and degradation of PDHA1 in CRC metabolism and metastasis. Integrating TCGA and Clinical Proteomic Tumor Analysis Consortium databases, proteomic, clinical, and metabolomic analyses were performed, revealing PDHA1 as a prognostic marker in CRC.

Metabolic Disruption Exacerbates Intestinal Damage during Sleep Deprivation by Abolishing HIF1α-Mediated Repair

November 15, 2024

[Cell Reports] Scientists found that chronic sleep deprivation led to colonic damage through continuous hypoxia. However, HIF1α was paradoxically dysregulated in the colon.

Metastasis of Colon Cancer Requires Dickkopf-2 to Generate Cancer Cells with Paneth Cell Properties

November 15, 2024

[eLife] Researchers reported that Dickkopf-2 was essential for the generation of cancer cells with Paneth cell properties during colon cancer metastasis.

LINC02139 Interacts with and Stabilizes XIAP to Regulate Cell Proliferation and Apoptosis in Gastric Cancer

November 15, 2024

[Communications Biology] Scientists revealed that LINC02139 was upregulated in gastric cancer (GC) cell lines and tissues and high LINC02139 expression was correlated with the advancement of GC in patients.

METTL3-Mediated N6-Methyladenosine Modification of MMP9 mRNA Promotes Colorectal Cancer Proliferation and Migration

November 15, 2024

[Oncology Reports] Investigators demonstrated that methyltransferase-like 3 (METTL3) expression and the N6‑methyladenosine levels were both upregulated in CRC and positively associated with clinical progression, based on the bioinformatics analysis of cancer databases.

Emerging Therapeutic Strategies for Wnt-Dependent Colon Cancer Targeting Macropinocytosis

November 15, 2024

[Cells & Development] The authors explore the connection between membrane trafficking and Wnt signaling, with a specific focus on macropinocytosis—an endocytic process involved in nutrient uptake that also plays a role in Wnt signal regulation.

Numab Therapeutics and Kaken Pharmaceutical Enter Collaboration and Option Agreement for Multi-specific Antibody ND081 for Treatment of Inflammatory Bowel Disease

November 15, 2024

[Numab Therapeutics (Globe Newswire)] Numab Therapeutics AG and Kaken Pharmaceutical Co., Ltd. announced a new collaboration and option agreement to develop ND081, a potential first-in-class multi-specific antibody for the treatment of inflammatory bowel disease.

The Drosophila Adult Midgut Progenitor Cells Arise from Asymmetric Divisions of Neuroblast-Like Cells

November 13, 2024

[Developmental Cell] Investigators showed that the Drosophila adult midgut progenitor cells arose from a population of endoderm cells, which exhibited multiple similarities with Drosophila neuroblasts.

Binghamton University Researcher to Aid Innovative Mayo Clinic Project to Treat Inflammatory Diseases

November 8, 2024

[BingUNews] Binghamton University (BingU) will play a key role in a federal grant of up to $42.8 million to develop an implantable device that acts as a living pharmacy to treat inflammatory diseases.

Enhancing Low-Dose Radiotherapy Efficacy with PARP Inhibitors via FBL-Mediated Oxidative Stress Response in Colorectal Cancer

November 8, 2024

[Oncogene] Scientists elucidated an association between the nucleolar protein Fibrillarin (FBL) and the oxidative stress response in colorectal cancer (CRC) tumors. Their findings revealed elevated expression of FBL in colorectal cancer, which positively correlated with oxidative stress levels.

Role of CD47 Gene Expression in Colorectal Cancer: A Comprehensive Molecular Profiling Study

November 7, 2024

[Journal For Immunotherapy of Cancer] Investigators analyzed the next-generation sequencing data of DNA and RNA from 14,287 colorectal cancer cases included in the data set of a commercial Clinical Laboratory Improvement Amendments-certified laboratory. The cases were divided into two groups based on the median value of CD47 gene expression levels.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.