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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
WAC Facilitates Mitophagy-mediated MSC Osteogenesis and New Bone Formation via Protecting PINK1 from Ubiquitination-Dependent Degradation
[Advanced Science] Scientists revealed that the levels of WW domain-containing coiled-coil adaptor (WAC) were diminished in both osteoporosis patients and osteoporosis mouse models. It played a pivotal function in facilitating MSC osteogenesis and enhancing new bone formation both in vitro and in vivo.
Renal Remodeling by CXCL10-CXCR3 Axis-Recruited Mesenchymal Stem Cells and Subsequent IL4I1 Secretion in Lupus Nephritis
[Signal Transduction and Targeted Therapy] Scientists elucidated that the migration of human umbilical cord-MSCs to the lupus nephritis kidney was driven by elevated levels of CXCL10, predominantly produced by glomerular vascular endothelial cells through the IFN-γ/IRF1-KPNA4 pathway.
Clinical Outcomes of Autologous Adipose-Derived Mesenchymal Stem Cell Combined with High Tibial Osteotomy for Knee Osteoarthritis Are Correlated with Stem Cell Stemness and Senescence
[Journal of Translational Medicine] In this prospective randomized trial, 45 knee osteoarthritis patients were divided into two groups: group 1 patients treated with high tibial osteotomy (HTO) alone and group 2 patients treated with HTO followed by intra-articular injection of autologous adipose-derived-MSCs.
Induced Hepatocyte-Like Cells Derived from Adipose-Derived Stem Cells Alleviates Liver Injury in Mice Infected with Echinococcus multilocularis
[Scientific Reports] Scientists investigated the potential of transplanted induced hepatocyte-like cells (iHEPs) in treating hepatic alveolar echinococcosis and described an efficient three-step protocol for the generation of iHEPs in vitro from ADSCs.
Chimeric Protein EWS::FLI1 Drives Cell Proliferation in Ewing Sarcoma via Aberrant Expression of KCNN1/SK1 and Dysregulation of Calcium Signaling
[Oncogene] Knowing that ion channels are involved in tumorigenesis, investigators studied the involvement of the KCNN1 gene, which encodes the SK1 potassium channel, in ewing sarcoma development.
Stem Cell Transplantation Extends the Reproductive Life Span of Naturally Aging Cynomolgus Monkeys
[Cell Discovery] Using a naturally aging cynomolgus monkey model, scientists found that transplanting human embryonic stem cells-derived MSC-like cells into the aging ovaries significantly decreased ovarian fibrosis and DNA damage, enhanced secretion of sex hormones, and improved fertility.
Mesenchymal Stem Cell-Derived Exosomes Carrying miR-486-5p Inhibit Glycolysis and Cell Stemness in Colorectal Cancer by Targeting NEK2
[BMC Cancer] The authors highlighted that human umbilical cord-MSC-derived exosomes (hUC-MSC-EXOs) miR-486-5p inhibited glycolysis and cell stemness in colorectal cancer (CRC) by targeting NEK2. They offer compelling evidence supporting the potential application of hUC-MSC-EXOs in the treatment of CRC.
Inhibition of Mitochondrial OMA1 Ameliorates Osteosarcoma Tumorigenesis
[Cell Death & Disease] Researchers observed elevated OMA1 expression in osteosarcoma (OS) tumor tissues from four patients with advanced OS. Knockout of OMA1 in OS cells significantly reduces OS tumor weight and size, and lung metastatic nodules in BALB/c nude mice.
B7-H3 Is Widely Expressed in Soft Tissue Sarcomas
[BMC Cancer] This retrospective analysis evaluated soft tissue sarcoma tumor specimens from patients with a variety of different subtypes. Specimens were evaluated by immunohistochemistry for expression and staining pattern of B7-H3 both in tumors and in associated vasculature.
Advancing Osteosarcoma 3D Modeling In Vitro for Novel Tumor Microenvironment-Targeted Therapies Development
[Journal of Controlled Release] Scientists reported the development and characterization of an innovative 3D model of osteosarcoma (OS), composed of OS tumor cells, immune cells and MSCs, that formed a multicellular tissue spheroid.
Management of Knee Osteoarthritis Using Bone Marrow Aspirate Concentrate: A Systematic Review
[British Medical Bulletin] The authors systematically reviewed the current literature on bone marrow aspirate concentrate (BMAC) in the management of knee osteoarthritis, giving an update on the current indications for the selection of the ideal patient and the preparations and efficacy of BMAC compared to other biological alternatives.
BioRestorative Therapies Receives Expanded Tissue License from New York State Department of Health
[BioRestorative Therapies, Inc. (Globe Newswire)] BioRestorative Therapies, Inc. announced that it has received a provisional license from the New York State Department of Health for the processing of allogeneic donor tissue material for the isolation, expansion and cryopreservation of various cell types, including stem cells, for medical research.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
