Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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The Postsynaptic Density in Excitatory Synapses Is Composed of Clustered, Heterogeneous Nanoblocks

March 27, 2025

[Journal of Cell Biology] Scientists used cryo-electron tomography to directly visualize the three-dimensional architecture and supramolecular organization of postsynaptic components in both synaptosomes and synapses from cultured neurons.

PI3Kβ Functions As a Protein Kinase to Promote Cellular Protein O-GlcNAcylation and Acetyl-CoA Production for Tumor Growth

March 27, 2025

[Molecular Cell] Investigators demonstrate that high glucose induces PI3Kβ binding to O-linked β-D-N-acetylglucosamine (O-GlcNAc) transferase (OGT) in glioblastoma cells, dependent on hexokinase 1-mediated OGT Y889 phosphorylation and subsequent p85α recruitment.

Tolebrutinib Regulatory Submission Accepted for Priority Review in the US for Patients with Multiple Sclerosis

March 26, 2025

[Sanofi] The US FDA is evaluating under priority review the regulatory submission of tolebrutinib to treat non-relapsing secondary progressive multiple sclerosis and to slow disability accumulation independent of relapse activity in adult patients.

Autonomic Dysfunction in Neurodegenerative Disease

March 26, 2025

[Nature Reviews Neuroscience] Neurodegenerative diseases are associated with impairments in autonomic function — the regulation of involuntary physiological processes. These autonomic impairments manifest in different ways and at different stages depending on the specific disease.

GSK, UK Dementia Research Institute (UK DRI) and Health Data Research UK (HDR UK) to Collaborate on First-of-Its-Kind Dementia Research Initiative

March 25, 2025

[GSK] GSK plc announced a major new research collaboration with the UK DRI and HDR UK to advance understanding of neurodegeneration with a first-of-its-kind dementia study.

How Microglia Contribute to the Induction and Maintenance of Neuropathic Pain

March 25, 2025

[Nature Neuroscience] Microglia respond to and modulate neuronal activity during establishment and persistence of neuropathic pain states, and microglia–neuron pathways provide targets that can be exploited to attenuate abnormal neuronal activity and provide pain relief.

Knowing the Enemy: Strategic Targeting of Complement to Treat Alzheimer Disease

March 25, 2025

[Nature Reviews Neurology] The authors provide justification, largely from preclinical mouse models but also from correlates with human tissue and biomarkers, for targeting specific complement components for therapeutic intervention in Alzheimer disease.

Neural Ensembles That Encode Nocifensive Mechanical and Heat Pain in Mouse Spinal Cord

March 25, 2025

[Nature Neuroscience] By means of genetic capturing, activity manipulation and single-cell RNA sequencing, researchers identified distinct neural ensembles in the adult mouse spinal cord encoding mechanical and heat pain.

Brain 5-Hydroxymethylcytosine Alterations Are Associated with Alzheimer’s Disease Neuropathology

March 25, 2025

[Nature Communications] Scientists reported a genome-wide profiling of 5-hydroxymethylcytosine in 1079 autopsied brains of older individuals and assessed its association with multiple measures of Alzheimer’s disease pathologies.

Enteric Neuronal Piezo1 Maintains Mechanical and Immunological Homeostasis by Sensing Force

March 25, 2025

[Cell] The authors established that the mechanosensor Piezo1 was functionally expressed in cholinergic enteric neurons.

Targeting HINT1 to Improve Synaptic Plasticity: Toward Loganin As a New Antidepressant Strategy

March 25, 2025

[Molecular Psychiatry] Scientists reported that loganin directly targeted histidine triad nucleotide-binding protein 1 (HINT1) to alleviate depressive-like behaviors. Overexpression of HINT1 in the hippocampus induces depressive-like behaviors.

Escitalopram for Agitation in Alzheimer’s Dementia: A Randomized Controlled Phase III Trial

March 25, 2025

[Nature Medicine] In this double-masked randomized placebo-controlled trial, investigators assessed the efficacy and safety of escitalopram in treating agitation in Alzheimer's disease after failure of a psychosocial intervention.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.