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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Obesity-Specific Improvement of Lung Cancer Outcomes and Immunotherapy Efficacy with Metformin
[JNCI-Journal of The National Cancer Institute] Investigators hypothesized that metformin could benefit obese and overweight patients with NSCLC. They retrospectively analyzed two clinical cohorts and employed complementary mouse models to test their hypothesis. One cohort included NSCLC patients with overweight BMI and non-overweight BMI who underwent lobectomy.
A STAT3–STING–IFN Axis Controls the Metastatic Spread of Small Cell Lung Cancer
[Nature Immunology] Researchers showed that, while STAT3 deletion restricted primary tumor growth, it paradoxically enhanced metastatic spread by promoting immune evasion.
Effect of Nicotinamide Riboside on Airway Inflammation in COPD: A Randomized, Placebo-Controlled Trial
[Nature Aging] In this randomized, double-blind, placebo-controlled clinical trial, scientists treated patients with stable COPD with the NAD+ precursor nicotinamide riboside for 6 weeks and followed-up 12 weeks later.
KLF5 Shapes Developing Respiratory Tubules by Inhibiting Actin Asymmetry in Epithelial Cells
[American Journal of Respiratory Cell and Molecular Biology] Researchers unveiled a critical role for the transcription factor KLF5, regulating actin asymmetry, inducing epithelial cell shape changes by balancing RHOA and CDC42 GTPase activity via RICH2.
Breathing New Insights into the Role of Mutant p53 in Lung Cancer
[Oncogene] The authors discuss the cellular responses controlled by p53 that contribute to tumor suppression, p53 mutant lung cancer mouse models, and characterisation of p53 mutant lung cancer.
LCRF and IASLC announce first Team Science Award grant
[The Lung Cancer Research Foundation] The Lung Cancer Research Foundation (LCRF) and the International Association for the Study of Lung Cancer (IASLC) announced their first IASLC – LCRF Team Science Research Grant. Dr. David Barbie will be leading the winning project, “Immune elimination of drug tolerant persister cells in oncogene-driven lung cancer.”
£4M Funding Renewal for Lung Cancer Research in Manchester and London
[Cancer Research UK] Scientists at Lung Cancer Centre of Excellence in Manchester and London will continue their groundbreaking research with up to £4m of funding support from ScottishPower.
m6A-Modified SNRPA Controls Alternative Splicing of ERCC1 Exon 8 to Induce Cisplatin Resistance in Lung Adenocarcinoma
[Advanced Science] The authors identified SNRPA as a spliceosome-related gene that potentially modulated resistance to platinum chemotherapy. Both the knockout or the knockdown of SNRPA via CRISPR/Cas9 and shRNA techniques could reverse the resistance of cisplatin-resistant LUAD cells to cisplatin.
Autologous Transplantation of P63+ Lung Progenitor Cells in Patients with Bronchiectasis: A Randomized, Single-Blind, Controlled Trial
[Cell Reports Medicine] Researchers investigated the safety and efficacy of autologous P63+ progenitor cell transplantation in a randomized, single-blind, controlled, phase I/II trial.
Non-Classical Action of Ku70 Promotes Treg Suppressive Function through a FOXP3-Dependent Mechanism in Lung Adenocarcinoma
[Journal of Clinical Investigation] Using a lung-colonizing tumor model of in mice with Treg-specific Ku70 deficiency, scientists demonstrated that deletion of Ku70 in Treg cells led to a stronger anti-tumor response and slower tumor growth due to impaired immune-suppressive capacity of Treg cells.
ZNF652 Exerts a Tumor Suppressor Role in Lung Cancer by Transcriptionally Downregulating Cyclin D3
[Cell Death & Disease] Investigators identified that ZNF652 was downregulated in human lung cancer tissues and cell lines. Low ZNF652 expression was associated with poor survival in lung cancer patients.
The Role of Baseline 18F-FDG PET/CT for Survival Prognosis in NSCLC Patients Undergoing Immunotherapy: A Systematic Review and Meta-Analysis
[Therapeutic Advances In Medical Oncology] Researchers investigated the prognostic ability of baseline 18F-FDG PET/CT in patients with non-small-cell lung cancer (NSCLC) receiving immunotherapy.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
