Glutamic-Pyruvic Transaminase 1 Deficiency–Mediated Metabolic Reprogramming Facilitates Colorectal Adenoma-Carcinoma Progression

Scientists analyzed transcriptomic profile changes in normal, advanced adenoma, and carcinoma tissues from patients with colorectal cancer (CRC), revealing that glutamic-pyruvic transaminase 1 (GPT1) in colorectal tissues was down-regulated during the N-A-C process and correlated with poor CRC prognosis.