TFF3 Drives Hippo Dependent EGFR-TKI Resistance in Lung Adenocarcinoma

The authors observed that trefoil factor 3 (TFF3) was a crucial mediator of the lung adenocarcinoma (LUAD) epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) response. TFF3 conferred intrinsic resistance to EGFR inhibition in LUAD by promotion of EGFR activation.