Another-Regulin Regulates Cardiomyocyte Calcium Handling via Integration of Neuroendocrine Signaling with SERCA2a Activity

To study the role of another-regulin (ALN) in cardiomyocytes, scientists generated ALN null mice and found that cardiomyocytes from these animals displayed enhanced Ca2+ cycling and contractility compared to wildtype mice, indicating enhanced SERCA2a activity.