 | | Vol. 13.21 – 4 September, 2024 |
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| Researchers treated patient-derived primary glioblastoma stem cell lines, an astrocyte cell line, and primary fibroblast cell lines with epigenetic drugs, and identified treatment-induced, transposable element-derived transcripts preferentially expressed in cancer cells.
[Nature Genetics] |
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 | | PUBLICATIONSListed by the impact factor of the journal |
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| Two new potent small-molecule inhibitors of Arf1, identified as DU101 and DU102, for cancer therapy were introduced. Preclinical tumor models demonstrated that these inhibitors triggered a cascade of aging in CSCs and enhanced anti-tumor immunity in mouse cancer and PDX models.
[Advanced Science] |
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| Investigators developed new approaches for selectively killing senescent-escape CSCs. High CD276 expression in multidrug-resistant breast cancer cells, facilitated immune evasion by low-immunogenic senescent escape CSCs.
[Biomaterials] |
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| Scientists investigated the role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia.
[Journal of Experimental & Clinical Cancer Research] |
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| Investigators analyzed single-cell RNA sequencing data from 12 patients with liver cancer and identified a subpopulation of macrophages characterized by elevated expression of SPP1. These SPP1+ macrophages induced upregulation of tumor stemness through a vitronectin-dependent paracrine mechanism.
[Cancer Letters] |
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| To investigate the gene and protein expression profiles of DRD4 in liver cancer stem cells (LCSCs) and non-LCSCs, scientists utilized transcriptome sequencing and Western blotting analysis.
[British Journal of Cancer] |
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| The dynamic expression patterns of Fos‑like antigen 1 (FOSL1) were investigated during the acquisition of cancer stem‑like properties using RNA sequencing, PCR, western blotting, and immunofluorescence.
[International Journal of Molecular Medicine] |
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| Researchers reported that the acid-sensing ion channel 3 isoform, usually absent in the central nervous system and present in the peripheral nervous system, was enriched in human glioblastoma cancer stem cells while poorly expressed in the healthy human brain.
[Scientific Reports] |
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| Scientists explored the effects of tripartite motif containing 24 (TRIM24) and zinc finger protein, X-linked (ZFX) on colorectal cancer cell stemness and 5-FU resistance.
[Journal of Chemotherapy] |
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| The authors discuss the in vitro and in vivo models that have been developed for studying neural stem cell quiescence and how these tools may be used to deepen biological understanding and to develop novel therapies targeting quiescent glioma stem cells.
[Trends In Neurosciences] |
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| Investigators explore the multifaceted role of the tumor suppressor BRCA1-associated protein 1 (BAP1) in cancer and placentation. Initially recognized for its tumor-suppressive properties, BAP1 has emerged as a key regulator at the intersection of tumorigenesis and placental development.
[Communications Biology] |
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| The Colorado Blood Cancer Institute at Presbyterian St. Luke’s Medical Center is leading the way in a type of stem cell therapy to treat autoimmune diseases, including multiple sclerosis.
[Denver7] |
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| October 2 – 4, 2024
Copenhagen, Denmark |
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| | Fred Hutch Cancer Center – Seattle, Washington, United States |
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| | Tulane University – New Orleans, Louisiana, United States |
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| | University of Oulu – Oulu, Finland |
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| | University Health Network – Toronto, Ontario, Canada |
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| | IDIBAPS Research Institute – Barcelona, Spain |
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