Multi-Armored Allogeneic MUC1 CAR T Cells Enhance Efficacy and Safety in Triple-Negative Breast Cancer

Using a multi-layered CAR T cell engineering strategy that allowed a synergy between attributes, investigators showed enhanced cytotoxic activity of MUC1 CAR T cells armored with PD1KO, tumor-specific interleukin-12 release, and TGFBR2KO attributes catered towards the triple-negative breast cancer tumor microenvironment.