Mitochondrial Serine Catabolism Safeguards Maintenance of the Hematopoietic Stem Cell Pool in Homeostasis and Injury

Researchers uncovered a distinct and heterogeneous serine metabolism within HSCs and identified mouse HSCs as a serine auxotroph whose maintenance relies on exogenous serine and the ensuing mitochondrial serine catabolism driven by the hydroxymethyltransferase 2-methylene-tetrahydrofolate dehydrogenase 2 axis.