Regulation of Temporal Cytokine Production by Co-Stimulation Receptors in TCR-T Cells Is Lost in CAR-T Cells

Scientists compared early and late production of IFN-gg, IL-2, and TNF-a production by T cells stimulated via TCR or CARs in the presence or absence ligands for CD2, LFA-1, CD28, CD27, and 4-1BB.