A Multidimensional Analysis Reveals Distinct Immune Phenotypes and the Composition of Immune Aggregates in Pediatric Acute Myeloid Leukemia

Scientists demonstrated that nearly one-third of pediatric AML cases had an immune-infiltrated bone marrow (BM), which was characterized by a decreased ratio of M2- to M1-like macrophages. They detected the presence of large T cell networks, both with and without colocalizing B cells, in the BM and dissected the cellular composition of T and B cell-rich aggregates using spatial transcriptomics.