ADP-Ribosylome Analysis Reveals Homogeneous DNA-Damage-Induced Serine ADP-Ribosylation across Wild-Type and BRCA-Mutant Breast Cancer Cell Lines

To understand the role of ADP-ribosylation (ADPr) in poly(ADP-ribose) polymerase 1 inhibitor (PARPi) sensitivity, scientists used liquid chromatography-tandem mass spectrometry to analyze ADPr in six breast cancer cell lines exhibiting different PARPi sensitivities.