Transmissible Gastroenteritis Virus Induces Inflammatory Responses via RIG-I/NF-κB/HIF-1α/Glycolysis Axis in Intestinal Organoids and In Vivo

The authors found that apical-out organoids were susceptible to transmissible gastroenteritis virus infection (TGEV), and the expression of representative inflammatory cytokines was significantly upregulated upon TGEV infection.