Generation of Induced Pluripotent Stem Cell Lines From Patients With LQT1 Caused by Heterozygous Mutations in the KCNQ1 Gene

Investigators generated two LQT1 iPSC lines with single nucleotide nonsense mutations, c.1031 C > T and c.1121 T > A in KCNQ1. Both lines exhibited typical iPSC morphology, expressed high levels of pluripotent markers, maintained normal karyotype, and possessed the capability to differentiate into three germ layers.