ASS1 Inhibits Triple-Negative Breast Cancer by Regulating PHGDH Stability and De Novo Serine Synthesis

Scientists discovered that argininosuccinate synthase (ASS1), a critical enzyme in the urea cycle, directly bound to phosphoglycerate dehydrogenase (PHGDH) and promoted its ubiquitination-mediated degradation to inhibit serine synthesis, consequently suppressing tumorigenesis.