 | | Vol. 12.20 – 24 May, 2023 |
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| Scientists demonstrated for the first time that ZDHHC21 palmitoyltransferase served as a key regulator of oxidative phosphorylation hyperactivity in acute myeloid leukemia (AML) cells.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers performed a comprehensive evaluation of metabolic adaptation to tyrosine kinase inhibitor treatment and its role in chronic myelogenous leukemia hematopoietic stem and progenitor cell persistence.
[Blood] |
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| Investigators conducted genome-wide CRISPR activation screening and identified OCT4 and SOX2 as the key factors that promoted sialylated cancer IgG expression.
[Cancer Research] |
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| Scientists reported that terminally exhausted (TTEX) cells actively participated in tumor progression by modulating CSCs. TTEX cells strongly correlated with elevated CSC frequency in poorly immune-infiltrated advanced human breast and ovarian carcinomas.
[Cancer Research] |
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| The chemoresistance and stemness of gastric cancer cells were observed by colony formation, CCK-8, sphere formation, and flow cytometry assays. Cell lines and animal models were utilized to investigate related functions.
[Cancer Letters] |
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| The authors characterized stem cell-related gene expression and identified stemness biomarker genes in acute myeloid leukemia. They calculated the stemness index based on transcription data using the one-class logistic regression algorithm for patients in the training set.
[Frontiers In Immunology] |
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| Scientists investigated the importance of Brg1 for established pancreatic ductal adenocarcinoma by using a mouse model with a dual recombinase system.
[Oncogene] |
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| To propagate gastric cancer cells as highly proliferative stem-cell spheroids in vitro, researchers initially used a similar method to that for colorectal cancer stem cells, which resulted in a low success rate.
[Cancer Science] |
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| Investigators found that the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) was upregulated in head and neck squamous cell carcinoma (HNSCC) tissues, and higher PCSK9 expression indicated poorer prognosis in HNSCC patients.
[iScience] |
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| Scientists found that B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) mRNA levels were elevated in nasopharyngeal carcinoma cell lines.
[Aging] |
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| To investigate the effects of Erianin on lung cancer stemness, researchers screened various concentrations of Erianin to ensure that it did not affect lung cancer cell viability.
[Environmental Toxicology] |
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| To provide an overview of the possible role of CSC‐derived exosomes and targeting strategies, the authors summarize relevant research progress and highlight the potential impact of detecting or targeting CSC‐derived exosomes on cancer treatment.
[Journal of Experimental & Clinical Cancer Research] |
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| As a partner in the Victorian Pediatric Cancer Consortium, Hudson Institute of Medical Research welcomes the commitment of $35 million, which will boost their efforts to find new treatments and cures, as well as improving quality of life for children who survive cancer.
[Hudson Institute of Medical Research] |
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| Two leaders from the Penn Medicine Abramson Cancer Center will be honored with 2023 Special Awards from the American Society for Clinical Oncology (ASCO), and Conquer Cancer, the ASCO Foundation, during the 2023 ASCO Annual Meeting.
[Penn Medicine News] |
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| June 4 – 7, 2023
Heidelberg, Germany |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Université de Lausanne – Lausanne, Switzerland |
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| | Georgia Cancer Center at Augusta University – Augusta, Georgia, United States |
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| | Virginia Tech – Washington, DC, United States |
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