 | | Vol. 12.14 – 12 April, 2023 |
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| scRNA-seq was conducted on 95 551 cells from endoscopic biopsies of low-grade intraepithelial neoplasia, well/moderately/poorly differentiated early gastric cardia adenocarcinoma, and their paired adjacent nonmalignant biopsy samples.
[Gut] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Single cell RNA sequencing of HPV16 infected compared to uninfected organoids identified 12 distinct keratinocyte populations, with a subset mapped to reconstruct their respective 3D geography in stratified squamous epithelium.
[Nature Communications] |
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| Researchers generated a genetically engineered mouse with prostate-specific expression of the ETS factor, ETV4, at lower and higher protein dosage through mutation of its degron.
[Science Advances] |
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| The authors investigated the alteration of glycosylation in colorectal cancer following long-term plasticizers exposure. They determined the profiles of cell surface N-glycomes by using mass spectrometry and found out the alterations of α2,8-linkages glycans.
[Environmental Pollution] |
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| CSCs and non-stem cancer cells were sorted from gastric cancer cells, and extracellular vesicles were isolated from CSCs.
[Journal of Translational Medicine] |
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| The serum concentration and intracellular expression level of stanniocalcin-1 (STC1) were quantified by ELISA and western blotting, respectively.
[Journal of Translational Medicine] |
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| In transcriptomic and protein expression analyses, scientists identified NOTCH1 signaling as one of the main pro-stemness pathways repressed by EC-8042 in osteosarcomas.
[Biomedicine & Pharmacotherapy] |
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| Researchers showed that Kruppel-like-factor 8 (KLF8) was required and sufficient for regulating CSC phenotypes and regulating transcription factors SOX2, NANOG, OCT4, and c-MYC.
[Frontiers In Oncology] |
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| DESeq2 was applied to analyze the differentially expressed genes. The mRNA stemness index was calculated by one-class logistic regression. The stemness-related cells were analyzed based on scRNA-seq dataset GSE166555.
[Cancer Medicine] |
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| The authors describe the structural features and functions of lysine demethylases (KDMs), the KDMs preferences of different cancers, and the mechanisms of drug resistance resulting from KDMs.
[Medicinal Research Reviews] |
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| Scientists review the biological features of gastric stem cells at various locations of the stomach under homeostatic conditions, as demonstrated by reporter mice, lineage tracing, and single cell sequencing.
[Cellular Oncology] |
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| Investigators highlight the properties of flavonoids particularly relevant for targeting breast CSCs to mitigate therapy resistance.
[Frontiers In Pharmacology] |
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| Oncolyze, which already holds an Orphan Drug Designation for its lead drug candidate OM-301 in treating acute myeloid leukemia, announced that the FDA has just granted OM-301 its second Orphan Drug Designation, for multiple myeloma.
[Oncolyze (Newswire)] |
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| April 30 – May 5, 2023
Barga, Italy |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | University of Southern California – Los Angeles, California, United States |
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| | University of Texas Health Science Center – San Antonio, Texas, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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