 | | Vol. 10.31 – 11 August, 2021 |
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| Scientists demonstrated that the CD10 transmembrane hydrolase expressed on a subset of carcinoma-associated fibroblasts supported tumor stemness and induced chemoresistance.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported a small molecule construct, AzCDF, that allowed the therapeutic targeting of breast CSCs and which was effective in normally refractory hypoxic tumor environments.
[Journal of the American Chemical Society] |
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| Bioinformatic analysis, quantitative mRNA and protein expression analysis, cell models of sarcoma by ectopic expression of EMX genes. Researchers measured tumorigenesis and populations enriched on stem cell phenotypes, either in vitro or in vivo.
[Journal of Experimental & Clinical Cancer Research] |
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| A natural product 5α-epoxyalantolactone (5α-EAL) was discovered as an anti-breast CSCs lead compound 5α-EAL was found to be able to notably suppress the function of ANXA2 by covalently targeting cysteine 9 of ANXA2.
[Journal of Medicinal Chemistry] |
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| Cadmium (Cd)-induced malignant transformation of human bronchial epithelia BEAS-2B cells was accomplished by a nine-month low dose Cd exposure. The Cd-exposed cells formed significantly more colonies in soft agar, displayed CSC-like properties and formed tumors in nude mice.
[Toxicological Sciences] |
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| Scientists identified a novel mechanism of biphasic activation of STAT3 in response to gp130-linked cytokines, including interleukin-6 (IL6), in which activation of STAT3 was prolonged by circumventing the negative regulatory mechanisms induced by its initial activation
[Translational Oncology] |
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| Expression of CSC markers was examined in 572 thyroid tumors from The Cancer Genome Atlas Thyroid Cancer database and tall cell variant and papillary thyroid carcinoma tumors by immunohistochemistry.
[Surgery] |
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| The authors demonstrated significant overexpression of ONECUT2 and down-regulation of hsa-miR-15a-5p in gastric cancer via bioinformatics analysis and in vitro assays.
[Experimental Biology and Medicine] |
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| Three datasets were used to perform the analysis to search for the key genes related to glioma stem cell, temozolomide resistance, and prognosis. The key gene for further research was selected by reviewing the previous studies.
[Biomed Research International] |
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| Scientists highlight recent advance in targeted polymeric nanoformulations that are coated with varying ligands and loaded with different therapeutic agents for directing to distinct targets in hematological malignancies.
[Journal of Controlled Release] |
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| The acquisition of stemness in CSCs has been accomplished through genetic and epigenetic rewiring following the metabolic switch.
[Stem Cell Reviews and Reports] |
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| Castle Biosciences, Inc. announced its continued collaboration with the Melanoma Research Foundation, a non-profit organization leading the melanoma community to transform melanoma from one of the deadliest cancers to one of the most treatable through research, education and advocacy.
[Castle Biosciences, Inc.] |
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| Trillium Therapeutics, Inc. announced that it has dosed the first TP53-mutated acute myeloid leukemia patient with TTI-622, an investigational checkpoint inhibitor of the innate immune system, in combination with azacitidine.
[Trillium Therapeutics, Inc.] |
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| | Incyte – Wilmington, Delaware, United States |
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| | MD Anderson Cancer Center – Houston, Texas, United States |
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| | Philipps University of Marburg – Marburg, Germany |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| Westwood Bioscience, Inc. – Los Angeles, California, United States |
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