 | | Vol. 10.22 – 9 June, 2021 |
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| Scientists generated an ultrasensitive 3D-metasensor to efficiently capture and investigate metastatic CSCs and magnified the vital premetastatic signals from a single cell.
[ACS Nano] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors proposed that a high-fat diet enhanced intestinal stemness and tumorigenicity by engaging a peroxisome proliferator-activated receptor-fatty acid oxidation program.
[Cell Reports] |
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| Scientists demonstrated that αSMA+ cancer-associated fibroblast in colorectal cancer (CRC) exerted tumor-restraining functions via BMP4/TGFβ1 paracrine signaling that served to suppress Lgr5+ CSCs and promoted anti-tumor immunity, ultimately limiting CRC progression.
[Oncogene] |
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| In addition to impacting stem cell proliferation during damage-induced intestinal regeneration, the role of RAL GTPases impacted EGFR-dependent tumorigenic growth in the intestine and in the human mammary epithelium.
[eLife] |
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| By probing a number of kinases downstream of integrin-β1, researchers determined that PI3K inhibition with either a tool compound or a compound in clinical trials robustly sensitized quiescent breast tumor cells seeded in organotypic bone marrow cultures to chemotherapy.
[Molecular Oncology] |
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| Investigators interrogated gene expression in separate microenvironments of glioblastoma organoid models that mimicked the transition between nutrient-rich and nutrient-poor pseudopalisading/perinecrotic tumor zones using spatial-capture RNA-sequencing.
[Acta Neuropathologica Communications] |
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| The authors identified a putative CSC population in immortalized and primary human ameloblastoma cells and examined possible therapeutic reagents to reduce the CSC population.
[Cell Proliferation] |
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| Investigators suggested that combined treatment with the DRD2/3 antagonist ONC201 and radiation improved the efficacy of radiation against glioblastoma (GBM) in vitro and in vivo through suppression of glioma-initiating cells without increasing toxicity in mouse models of GBM.
[Radiotherapy and Oncology] |
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| Researchers provided in vivo evidence that RAD51-Associated Protein 1(RAD51AP1) played a critical role in colorectal cancer (CRC) growth and drug resistance by regulating CRC stem cell self-renewal.
[Molecular Cancer Research] |
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| Cancer cell stemness-associated lncRNAs and their relevance in the prediction of clinical prognosis remain largely unexplored. Through the transcriptome-wide screen, scientists identified a total of 136 liver CSC-associated lncRNAs.
[DNA and Cell Biology] |
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| | | The authors discuss the signaling programs that simultaneously induce CSCs and reprogram the immune response to facilitate tumor immune evasion, metastasis, and recurrence.
[Nature Reviews Cancer] |
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| Scientists review how dysregulation of tissue-level force increases the risk of malignancy, promotes tumor progression, and can induce a stem-like phenotype in tumor cells to drive tumor aggression and treatment resistance.
[Developmental Cell] |
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| bluebird bio, Inc. announced that the FDA has lifted the clinical holds on the Phase I/II HGB-206 and Phase III HGB-210 studies of LentiGlobin for sickle cell disease (SCD) gene therapy (bb1111) for adult and pediatric patients with SCD, and the Phase 3 Northstar-2 and Northstar-3 studies of betibeglogene autotemcel gene therapy for adult, adolescent and pediatric patients with transfusion-dependent β-thalassemia.
[bluebird bio, Inc.] |
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| June 21 – 24, 2021
Virtual |
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| | City of Hope – CMonrovia, California, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | UT Southwestern Medical Center – Dallas, Texas, United Statess |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | Columbia University Medical Center – New York, New York, United States |
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