 | | Vol. 9.39 – 14 October, 2020 |
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| Scientists demonstrated that, with direct cell-cell contact, tumor microenvironment-derived endothelial cells provided the Notch ligand Jagged1 to neighboring breast cancer stem cells, leading to Notch1-dependent upregulation of Zeb1.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators analyzed the levels of mRNA transcripts in serum‐starved primary WT and KO mouse hepatocytes using RNA sequencing data, and found that cyclic AMP response element‐binding protein target genes were downregulated.
[EMBO Journal] |
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| Extracellular matrix-rich tumors exhibited a stem cell-like gene expression profile and superior tumor-initiating capacity, whereas such features were absent in responder tumors.
[Cancer Immunology Research] |
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| Investigators report that NAD-dependent deacetylase sirtuin-1 (SIRT1) signaling regulated colorectal cancer (CRC) stemness by enhancing expression of CD24, a CRC stemness promoter.
[Cancer Research] |
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| Scientists found that SUV39H1 was down-regulated in a variety of leukemias, including MLL-r AML, as compared with normal individuals.
[Oncogene] |
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| The authors showed that Mlc1 was expressed in human stem-like glioblastoma (GBM) cells and was linked to the development of primary and recurrent GBM.
[Oncogene] |
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| Researchers observed that ras-association domain family protein1 isoform A (RASSF1A) expression inhibited the malignant phenotypes of nasopharyngeal carcinoma (NPC) cells. Stable silencing of RASSF1A in NPC cell lines induced self-renewal properties and tumorigenicity in vivo/in vitro and the acquisition of an invasive phenotype in vitro.
[Cell Death & Disease] |
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| Single-cell sequencing data from seven surgical specimens of glioblastoma patients and patient-derived glioma stem cells co-cultured with peripheral leukocytes were used for the analysis.
[Frontiers in Immunology] |
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| Scientists investigated the role of TAp63α in colorectal cancer stem cells and the effects of sulforaphane on TAp63α. They found that TAp63α was upregulated in spheres with stem cell properties compared to the parental cells.
[Oncogenesis] |
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| Investigators evaluated the potential anti-tumor effect of Tideglusib, an irreversible glycogen synthase kinase (GSK-3β) inhibitor drug, on three human neuroblastoma cell lines, SK-N-SH, SH-SY5Y, and IMR-32.
[Pharmacological Reports] |
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| The authors advocate with substantial evidence the dynamic model of tumor propagation by exploring the specific cell types, reversible phenotypic plasticity between the tumorigenic leader seeds and the supporting follower cancer cells both in circulation and in solid tissue to accurately decipher tumor promoting clones and its role in metastatic dissemination and tumor re-growth.
[Translational Oncology] |
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| WindMIL Therapeutics (WindMIL) and Stephenson Cancer Center announced that the first patients have been identified in an investigator-sponsored study for the collection of bone marrow from patients with renal and urothelial carcinomas. The study will evaluate generating marrow infiltrating lymphocytes for these patients through WindMIL’s proprietary cellular activation and expansion process.
[WindMIL Therapeutics (Globe Newswire, Inc.)] |
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| January 25 – January 28, 2021
Virtual |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | The University of Chicago – Chicago, Illinois, United States |
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| | The Mayo Clinic – Jacksonville, Florida, United States |
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| | The University of Georgia – Athens, Georgia, United States |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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