Cancer Stem Cell News Volume 9.14 | Apr 15 2020

TOP STORY

Prostate-Specific Antigen Dynamics Predict Individual Responses to Intermittent Androgen Deprivation

Researchers simulated prostate-specific antigen dynamics, with enrichment of prostate cancer stem-like cells during treatment as a plausible mechanism of resistance evolution. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Selective Inhibition of Cancer Cell Self-Renewal through a Quisinostat-Histone H1.0 Axis

Scientists showed that cancer cells could be selectively deprived of self-renewal ability by interfering with their epigenetic state. [Nat Commun] Full Article

TGF-β1 Secreted by Pancreatic Stellate Cells Promotes Stemness and Tumorigenicity in Pancreatic Cancer Cells through L1CAM Downregulation

Cells with reduced expression of L1 cell adhesion molecule (L1CAM) harbored enhanced stemness potential and tumorigenicity. Inactivation of TGF-β1 signaling in pancreatic stellate cells strongly reduced the aggressiveness of pancreatic ductal adenocarcinoma cells. [Oncogene] Full Article

A Cancer Stem Cell-Like Phenotype Is Associated with miR-10b Expression in Aggressive Squamous Cell Carcinomas

At the functional level, overexpression of miR-10b conferred the stem cell-characteristic of 3D-spheroid formation capacity to keratinocytes. [Cell Commun Signal] Full Article

Combined Blockade of TGf-β1 and GM-CSF Improves Chemotherapeutic Effects for Pancreatic Cancer by Modulating Tumor Microenvironment

After treated by gemcitabine, both human and murine pancreatic cancer cell lines expressed higher level of immune check points, pancreatic CSC markers and varieties of immunosuppressive factors. [Cancer Immunol Immunother] Abstract

KIAA1429 Promotes Osteosarcoma Progression by Promoting Stem Cell Properties and Is Regulated by miR-143-3p

Functional investigations demonstrated that KIAA1429 silencing could attenuate proliferation, migration and invasion abilities of osteosarcoma in vitro, as well as tumor growth in vivo. [Cell Cycle] Abstract

miR-206 Inhibits Liver Cancer Stem Cell Expansion by Regulating EGFR Expression

Functional studies revealed that a forced expression of miR-206 inhibited liver CSCs expansion by suppressing the dedifferentiation of hepatoma cells and attenuating the self-renewal of liver CSCs. [Cell Cycle] Abstract

Identification of Very Small Cancer Stem Cells Expressing Hallmarks of Pluripotency in B16F10 Melanoma Cells and Their Reoccurrence in B16F10-Derived Clones

Very small cancer stem cells were found in B16F10-derived clones after three to five consecutive passages, where they occur as single cells or as small colonies, nevertheless, always using melanoma cells as feeders. These cells formed melanospheres enriched with Oct4-and ALDH1/2-positive cells. [Exp Cell Res] Abstract

Genetic, Epigenetic and Genomic Mechanisms of Methionine Dependency of Cancer and Tumor-Initiating Cells: What Could We Learn From Folate and Methionine Cycles

Methionine dependency involved the abnormal expression of 1-CM genes in CSCs. It was related to an increased demand for methionine and SAM, which was not compensated by the increased production of formate by glycine decarboxylase pathway in lung cancer tumor spheres. [Biochimie] Abstract

WIP1 Promotes Cancer Stem Cell Properties by Inhibiting p38 MAPK in NSCLC

Researchers identified WIP1, a p38 phosphatase frequently overexpressed in cancer, as a suppressor of p38 in a pathway that regulated CSC properties in non-small-cell lung cancer (NSCLC). [Signal Transduct Target Ther] Full Article

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JNK Signaling in Stem Cell Self-Renewal and Differentiation

The authors review current knowledge of C-JUN N-terminal kinases (JNK) signaling in CSCs and discuss its role in maintaining the CSC phenotype. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

MEI Pharma and Kyowa Kirin Announce Global License, Development and Commercialization Agreement for ME-401

MEI Pharma, Inc. and Kyowa Kirin Co., Ltd. jointly announced that the companies have entered into a global license, development and commercialization agreement to further develop and commercialize MEI’s ME-401, an oral, once-daily, investigational drug-candidate, selective for phosphatidylinositol 3-kinase delta, in clinical development for the treatment of B-cell malignancies. [MEI Pharma, Inc.] Press Release

WHO’s Tedros, Expressing ‘Regret’ over Trump Move to Cut Funding, Says His Focus Is on ‘Saving Lives’

The head of the World Health Organization expressed “regret” that President Trump intends to cut off US funding to the agency over its handling of the coronavirus, but pointedly avoided criticizing the US move. [STAT News] Editorial

Ending Coronavirus Lockdowns Will Be a Dangerous Process of Trial and Error

After the novel coronavirus made its way from China around the world, one country after another adopted harsh measures to stop SARS-CoV-2 from spreading and overwhelming hospitals. They have hit the pause button on their economies and their citizens’ lives, stopping sports events, religious services, and other social gatherings. [ScienceInsider] Editorial

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NEW PhD Positions – Head and Neck Cancer Stem Cells (The Mildred Scheel Nachwuchszentrum for Cancer Research)

NEW Scientist – Stem Cells and Cellular Biology (Athersys, Inc.)

Postdoctoral Positions – DNA Repair in Leukemia (Temple University School of Medicine)

Associate Professor – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Postdoctoral Position – Glioma Epigenomic Research (NIH National Cancer Institute)

Postdoctoral Fellow – RAS Proteins and Cancer Cell Stemness (University of Luxembourg)

Postdoctoral Position – Leukemia and Cancer Stemness (Moores Cancer Center, UC San Diego)

Research Fellow – Leukemia Stem Cell Research (Dana Farber Cancer Institute)

Postdoctoral Fellow – Breast Cancer Stem Cells (Albert Einstein College of Medicine)

Postdoctoral Scientist – Stem Cell Biology in Leukemia (University of Manchester)

Postdoctoral Fellow Position – RAS Cancer Cell Biology (University of Luxembourg)

Postdoctoral Researcher – Cancer Cell Invasiveness and Cancer Stem Cells (Cancer Research Center of Lyon)

Postdoctoral Associate – Glioma Stem Cell Biology (Cornell University)

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