 | | Vol. 11.16 – 27 April, 2022 |
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| Scientists revealed a novel function of chaperone-mediated autophagy as an intrinsic regulator of glioma stem cell tumorigenic properties and highlighted its relevance in glioblastoma progression.
[Autophagy] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors examined the mechanism by which nicotine promoted lung cancer brain metastasis. They conducted a retrospective analysis of 810 lung cancer patients with a smoking history and assessed brain metastasis.
[Oncogene] |
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| Researchers uncovered penfluridol suppressed in vitro cell growth and in vivo tumorigenicity of various renal cell carcinoma (RCC) cell lines and enhanced the Sutent-triggered growth inhibition on clear cell RCC cell lines.
[Cell Death & Disease] |
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| Scientists compared the signature of CD34+ stem/progenitor cells collected from chronic myeloid leukemia individuals with that of healthy donors and observed significant changes in the abundance of enzymes associated with aerobic central carbonate metabolic pathways.
[Cell Death & Disease] |
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| SLFN11 expression was evaluated in tumor samples and characterized in circulating tumor cells (CTC) longitudinally to determine its potential role as a biomarker of response.
[British Journal of Cancer] |
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| The authors demonstrated that the molecular mechanisms of angiopoietin-like protein 1 (ANGPTL1) in colorectal CSC progression may have provided a novel therapeutic strategy for colorectal cancer.
[Clinical Science] |
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| Researchers reported that the voltage-gated calcium channel α2δ1 subunit-positive tumor-initiating cells of hepatocellular carcinoma specifically secreted LOX, forming a stiff extracellular matrix that was sufficient to drive the formation of tumor-initiating cells with a stiff mechanical trait.
[Carcinogenesis] |
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| Investigators explored the effect of colorectal cancer (CRC) stem cells-derived exosomes conveying miR-17-5p on CRC.
[Cell Death Discovery] |
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| The remarkable activity of complex 1 was observed not only in rhabdomyosarcoma cells cultured in 2D monolayers but, more importantly, also in 3D spheroids, which resembled in many aspects solid tumors and served as a promising model to mimic the in vivo situation.
[Chemico-Biological interactions] |
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| The viability, proliferation, stemness, and migration of CD133+/CD44+, CD133−/CD44−, and colorectal cancer cells after transfection or the co-culture with exosomes were detected by MTT, colony formation, spheroid, and wound healing assays, respectively.
[Bioengineered] |
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| Scientists evaluate the mechanism of cancer stemness maintenance of liver cancer stem cells (LCSCs) and discuss promising treatments for eradicating LCSCs.
[Cell Death & Disease] |
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| Allogene Therapeutics, Inc. announced that the US FDA has granted orphan-drug designation to ALLO-605, the company’s next-generation allogenic CAR T product candidate targeting BCMA for the treatment of multiple myeloma.
[Allogene Therapeutics, Inc.] |
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| May 12 – May 14, 2022
Yokohama, Japan |
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| Johns Hopkins University – Baltimore, Maryland, United States |
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| | McGill University – Montreal, Quebec, Canada |
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| Cyprus Cancer Research Institute – Nicosia, Cyprus |
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| | The University of Hong Kong – Hong Kong, China |
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| Luxembourg Institute of Health – Strassen, Luxembourg |
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