Dynamic Synovial Fibroblasts Are Modulated by NBCn1 as a Potential Target in Rheumatoid Arthritis

Scientists suggested that inflammatory mediators in synovial fluid, including TNF-α, recruited sodium bicarbonate cotransporter n1 (NBCn1) to the plasma membrane of fibroblast-like synoviocytes to provide dynamic properties and that modulation of NBCn1 could be developed into a therapeutic strategy for rheumatoid arthritis.