Single-Cell RNA Sequencing Coupled to TCR Profiling of Large Granular Lymphocyte Leukemia T Cells

Scientists showed single-cell T cell receptor (TCR) coupled with RNA sequencing of CD3+ T cells from 13 patients, sampled before and after alemtuzumab treatments. Effector memory T cells and loss of TCR repertoire diversity were prevalent in T cell large granular lymphocyte leukemia.