UVB-Mediated DNA Damage Induces Matrix Metalloproteinases to Promote Photoaging in an AhR- and SP1-Dependent Manner

Investigators showed that matrix metalloproteinase 2, which degrades type IV collagen, was abundantly expressed in human skin, increased with age in sun-exposed skin, and correlated robustly with aryl hydrocarbon receptor (AhR), a transcription factor directly activated by UV-generated photometabolites.