Novel Fragile X Syndrome 2D and 3D Brain Models Based on Human Isogenic FMRP-KO iPSCs

By
Justin.choi
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Scientists generated 2D and 3D in vitro human FXS model systems based on isogenic fragile X mental retardation protein knock-out mutant and wild-type human induced pluripotent stem cell (hiPSC) lines.
[Cell Death & Disease]
Brighi, C., Salaris, F., Soloperto, A., Cordella, F., Ghirga, S., de Turris, V., Rosito, M., Porceddu, P. F., D’Antoni, C., Reggiani, A., Rosa, A., & Di Angelantonio, S. (2021). Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs. Cell Death & Disease, 12(5), 1–22. https://doi.org/10.1038/s41419-021-03776-8 Cite
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