[Prostate Cancer and Prostatic Diseases] Scientists evaluated the impact of upfront therapy for metastatic hormone-sensitive prostate cancer on outcomes in real-world clinical practice in the United States.

[Oncogene] Using human prostate cancer and CRPC cell line models, scientists demonstrated that TBX2 downregulated androgen receptor and upregulated glucocorticoid receptor through direct transcriptional regulation.

[Cancer Communications] Scientists identified a subset of prostate cancer cells that exhibited resistance to radiotherapy, characterized by a reduced antigen presentation capability, which enhanced their ability to evade immune detection and resist cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockade.

[Cell Death Discovery] Through network pharmacology and molecular docking, researchers explored the underlying mechanisms of oleanolic acid and aspirin against colorectal cancer.

[Cell Death & Disease] Researchers investigated the role of TNF receptors-associated factors 6 (TRAF6) in 5-fluorouracil (5-FU) resistant gastric cancer.

[Cell Death & Disease] Researchers explored the role played by the major phosphatidylinositol (PI) derivative, phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], in Crohn’s disease pathogenesis.

[Advanced Science] After demonstrating that ECM stiffness could affect phenotypes of primary liver cancers, researchers used intrahepatic cholangiocarcinoma to further explore the specific mechanisms underlying the impact of ECM stiffness on the progression of cancer and the effects of the application of anticancer strategies targeting ECM stiffness.

[Journal of Experimental & Clinical Cancer Research] Although anti-tumorigenic properties of cancer-associated fibroblasts (CAFs) have been reported, the majority of research demonstrates a pro-tumorigenic role for CAFs via (in)direct signaling to cancer cells, immunomodulation and ECM remodeling.

[Biofabrication] Scientists devised a new strategy for activating fibroblasts into myofibroblasts under prolonged and continuous exposure to the fibrotic environment, and developed a promising biomimetic nanoplatform for effective treatment of dysregulated chronic wound healing.

[Journal of Controlled Release] Topical administration of growth factor proteins-incorporated, self-crosslinkable hydrogels to the incision wound area effectively regenerated the skin, with rapid reconstruction of ECM.

[Circulation] Scientists demonstrated that paternally expressed gene 3 (Pw1) imprinting was disrupted after injury and revealed a novel role for the downstream target phosphoribosylformylglycinamidine synthase in ECM production and cardiac fibrogenesis.

[Signal Transduction and Targeted Therapy] Cilia, the ECM, epigenetic modifications, and hypoxia conditions play important roles in cardiac development. These factors play crucial roles at one or even multiple stages of cardiac development.