[Nature Communications] Scientists showed that the small hydrolyze guanosine triphosphate Rab7a strongly enhanced the activity of TPC2 and that effects of TPC2 on melanoma hallmarks, in vitro and in vivo strongly depended on the presence of Rab7a.

[iScience] In the absence of CFTR protein, centroacinar cells adopted a bi-potent progenitor-like state associated with enhanced WNT/β-Catenin, TGFβ and AKT signaling. The authors showed that the level of CFTR protein, not its channel function, regulated PDX1 expression.

[Cell Reports] Using a combination of gain- and loss-of-function approaches in chicken and mouse embryonic models, as well as mouse ESCs, scientists observed that manipulating the level of netrin1 specifically altered the patterning of the bone morphogenetic protein (Bmp)-dependent dorsal interneurons (dIs), dI1–dI3.

[Molecular Therapy - Nucleic Acids] Investigators discovered sharp peaks of CHD6, as the first member of CHD family for housekeeping process, binding only to the promoter region of genes in C4-2 cell line. These genes, with conserved sharp CHD6 peaks across tumor cells, likely represented housekeeping genes ADNP and GOLGA5.

[Texas Tech Now] Drs. Danielle Levitt and Hui Ying Luk from Texas Tech University will study the effects of heat therapy on older prediabetic adults, thanks to a five-year grant of roughly $3.5 million funded by the National Institute on Aging.

[Australian Manufacturing] The Centenary Institute has received funding from the RT Hall Trust to propel pioneering cancer research. The research will focus on improving the safety and efficacy of CAR-T cell therapy in treating pancreatic cancer.

[Nature Materials] Researchers developed synthetic hydrogels mimicking the lymphoid tissue microenvironment, enabling human germinal centres from tonsils and peripheral blood mononuclear cell-derived B cells.

[Journal of Immunotherapy of Cancer] Investigators conducted a high-throughput screen to identify molecules that could enhance primary human NK cell function. After compound validation, they investigated the effect of the top-performing compounds on dysfunctional NK cells that were generated by a newly developed in vitro platform.

[CPT-Pharmacometrics & Systems Pharmacology] Scientists developed a multiscale cellular kinetic–pharmacodynamic model using case studies from CD19/CD22 and GPRC5D/BCMA autologous CAR-Ts.

[Journal of Immunotherapy of Cancer] Researchers demonstrated that NK cells underpin the efficacy of combined PD-1/CTLA-4 blockade in brain metastases by orchestrating the "responder" molecular profile in tumors, and by controlling the intratumoral abundance of CD8+ T cells through regulation of multiple key molecular mediators of T cell trafficking.

[Ecotoxicology and Environmental Safety] Investigators advanced network toxicology strategies to efficiently investigate the putative toxicity and underlying molecular mechanisms of environmental pollutants, focusing on autoimmune diseases induced by bisphenol A exposure.

[Scientific Reports] To further understand the transcription events associated with this gene, scientists performed full-length RNA-Seq on 12 B-cell lines. They identified new exons, new splice events and new splice sites, leading to the discovery of 38 RHOH mRNA molecules, 27 of which have never been described before.