[Nature Materials] Researchers developed synthetic hydrogels mimicking the lymphoid tissue microenvironment, enabling human germinal centres from tonsils and peripheral blood mononuclear cell-derived B cells.

[Journal of Immunotherapy of Cancer] Investigators conducted a high-throughput screen to identify molecules that could enhance primary human NK cell function. After compound validation, they investigated the effect of the top-performing compounds on dysfunctional NK cells that were generated by a newly developed in vitro platform.

[CPT-Pharmacometrics & Systems Pharmacology] Scientists developed a multiscale cellular kinetic–pharmacodynamic model using case studies from CD19/CD22 and GPRC5D/BCMA autologous CAR-Ts.

[Journal of Immunotherapy of Cancer] Researchers demonstrated that NK cells underpin the efficacy of combined PD-1/CTLA-4 blockade in brain metastases by orchestrating the "responder" molecular profile in tumors, and by controlling the intratumoral abundance of CD8+ T cells through regulation of multiple key molecular mediators of T cell trafficking.

[Ecotoxicology and Environmental Safety] Investigators advanced network toxicology strategies to efficiently investigate the putative toxicity and underlying molecular mechanisms of environmental pollutants, focusing on autoimmune diseases induced by bisphenol A exposure.

[Scientific Reports] To further understand the transcription events associated with this gene, scientists performed full-length RNA-Seq on 12 B-cell lines. They identified new exons, new splice events and new splice sites, leading to the discovery of 38 RHOH mRNA molecules, 27 of which have never been described before.

[Microbes and Infection] The authors investigated the role of Sh-TSP-2, Sh-TSP-6 and Sh-TSP-23, which were expressed in the parasite’s tegument and extracellular vesicles. Immature dendritic cells from unexposed healthy donors were stimulated with these proteins to evaluate maturation maker expression and cytokine production.

[Oral Oncology] Scientists investigated differential immune checkpoint molecule (ICM) expression by HPV status using RNA sequencing data to identify additional ICM targets that may complement anti-PD1 antibodies.

[Journal of Immunological Methods] Investigators tested different antigen presenting cells isolated from controls, CD19+ B cells, CD11c+CD14+ and CD11c+CD14neg monocytes, CD11c+CD14negCD16+ and CD16neg dendritic cells.

[Human Immunology] Given the apparent involvement of the immune system in recurrent implantation failure (RIF) and the modulatory effect of lncRNAs on the immune system, the authors aim to delve into the role of lncRNAs in immune system modulation and their potential contribution to RIF.

[Quell Therapeutics, Ltd. (Globe Newswire)] Quell Therapeutics, Ltd. announces that AstraZeneca has selected a candidate to progress in the Type 1 Diabetes Treg cell therapy program.

[Communications Biology] Scientists focused on treatment responses of 3D skin replicas. Cytokine-priming of skin organoids induced psoriatic features like inflammation, antimicrobial peptides, hyperproliferation, and impaired differentiation.