[Nature Reviews Drug Discovery] Investigators review the dynamics of the tumor microenvironment with an emphasis on tumor innervation by the peripheral nervous system, as well as current preclinical and clinical evidence of the benefits of targeting the nervous system in cancer.

[Science] Researchers used primary cultured volar (sole) or nonvolar (scalp) fibroblasts from healthy volunteers to test for distinctive responses to pressure, capacity for modifying skin identity in bioprints, and potential cell therapy through autologous engraftment of fibroblasts in a clinical trial.

[ACS Nano] Investigators designed an effective hydrogel microneedle patch loaded with stem cell-derived mitochondria-rich extracellular vesicles to gradually release and deliver mitochondria into the wound tissues and boost wound healing.

[Nature] Investigators examined the transcriptome, chromatin accessibility, and methylome of neural stem cells and their progeny, and of astrocytes from the striatum and cortex in the healthy and ischaemic adult mouse brain.

[Nature Communications] Researchers reported that autocrine and paracrine clusterin suppressed astrocytic clearance of myelin debris and oligodendrocyte precursor cells differentiation, representing a potential pathological factor contributing to remyelination failure in MS models.

[Scientific Reports] Scientists developed an in vitro tumor invasion assay to investigate cell invasiveness in tumor spheroids under a chemotactic stimulus.

[Hong Kong Baptist University (PR Newswire)] The Centre for Chinese Herbal Medicine Drug Development (CDD) at Hong Kong Baptist University (HKBU) has achieved a significant milestone in developing a novel Chinese herbal formulation for ulcerative colitis remission maintenance. Following a submission of Investigational New Drug application for CDD-2103 to the National Medical Products Administration, CDD has received its authorization for clinical trial.

[Debbie's Dream Foundation (Longview News-Journal)] Debbie's Dream Foundation: Curing Stomach Cancer proudly recognizes Dr. Valerie O'Brien for her groundbreaking research into the link between Helicobacter pylori and gastric cancer.

[Circulation Research] Systems analyses integrating single-cell RNA sequencing and complementary immunologic approaches characterized key resolving characteristics as well as defining markers of reprogrammed monocytes trained by 4-phenylbutyric acid (4-BPA).

[Journal of Clinical Investigation] Researchers found that Parkin, an E3 ubiquitin ligase altered in Parkinson’s Disease was epigenetically silenced in cancer and its re-expression by clinically approved demethylating therapy stimulated transcription of a potent IFN response in tumor cells.

[Nature] Researchers described a γδ T cell–IL-3 signaling axis that controlled the allergen responsiveness of cutaneous sensory neurons.

[Immunity] Investigators generated Treg cell-specific lymphocyte activation gene 3 (Lag3)-mutant mouse models and found that Lag3 was essential for Treg cell control of autoimmunity.