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[Leukemia] While mutant mice exhibited mild defects in peripheral blood, they displayed significant hematopoietic abnormalities in the bone marrow, including a reduction in hematopoietic stem cell function and intrinsic biases toward specific stem cell subsets that differed from previous models of GATA2 loss.

[Nature Communications] Scientists showed the application of CRISPR/Cas9 to achieve >90% CCR5 editing in human, mobilized hematopoietic stem progenitor cells, resulting in a transplant that underwent normal hematopoiesis, produced CCR5 null T cells, and rendered xenograft mice refractory to HIV infection.

[Journal of Clinical Oncology] The TROPION-Lung05 Phase II trial evaluated the safety and clinical activity of datopotamab deruxtecan in patients with advanced NSCLC with actionable genomic alterations progressing on or after targeted therapy and platinum-based chemotherapy.

[Journal of Clinical Oncology] Investigators conducted a randomized Phase II trial to evaluate efficacy and safety of dual-HER2 inhibition against standard-of-care anti-EGFR antibody–based therapy as second/third-line treatment in HER2-positive metastatic colorectal cancer.

[Nature Medicine] Scientists evaluated the efficacy and safety of the radiation–immune checkpoint inhibitor combination in patients with locally advanced rectal cancer in a Phase II, randomized trial conducted in eight major colorectal cancer centers in Beijing.

[Journal of Hematology & Oncology] Anlotinib in combination with continuation of EGFR-tyrosine kinase inhibitors (TKIs) prolonged the clinical benefit of EGFR-TKIs, demonstrating favorable survival outcomes and manageable toxicity in NSCLC treated with EGFR-TKIs and had specific progression modes, such as gradual progression.

[Brain] Scientists identified PPARγ as an enriched transcription factor in the dysfunctional oligodendrocyte precursor cells (OPCs) accumulated in CNS demyelinated lesions. Its expression increased during OPC differentiation and myelination and was closely related to the process of CNS demyelination/remyelination.

[Cancer Communications] This Phase II, single-arm, prospective study aimed to explore appropriate neoadjuvant treatment strategies for HR+/HER2- breast cancer patients.

[American Journal of Hematology] Patients with newly diagnosed B-cell acute lymphoblastic leukemia received up to four cycles of hyper-CVAD followed by four cycles of blinatumomab. Inotuzumab ozogamicin 0.3 mg/m2 was added on days one and eight to two cycles of high-dose methotrexate and cytarabine, and two cycles of blinatumomab.

[EMBO Journal] Using a genetic model of caspase inhibition in beta cells coupled with mathematical modeling, scientist discovered an onset of beta-cell death in juvenile zebrafish, which regulated beta-cell mass.

[Annals of Neurology] Researchers aimed to characterize amyloid-β (Aβ) protofibril (PF) captured by lecanemab in human cerebrospinal fluid from living participants with different stages in Alzheimer's Disease, which enabled an enhanced understanding of the dynamic changes of lecanemab-associated Aβ-PF in vivo.

[Journal For Immunotherapy of Cancer] Functionally, researchers confirmed cyclic AMP response element binding protein 3-like protein 1 (CREB3L1) contributing to PDAC malignant progression including growth and metastasis by multiple in vitro and in vivo models.