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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
miR-224 Activates Cancer-Associated Fibroblasts to Enhance Lung Cancer Cell Migration and Invasion by Targeting Akirin1
[Scientific Reports] Scientists utilized global microRNA (miRNA) expression profiling to identify specific miRNAs responsible for reprogramming normal lung fibroblasts into cancer-associated fibroblasts.
The Fibronectin-Targeting PEG-FUD Imaging Probe Shows Enhanced Uptake during Fibrogenesis in Experimental Lung Fibrosis
[Respiratory Research] Investigators demonstrated the binding of PEGylated fibronectin-binding polypeptide (PEG-FUD) to the fibrotic lung throughout the course of bleomycin-induced murine model of pulmonary fibrosis.
Aspergillus fumigatus Is Responsible for Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease Exacerbation
[Respiratory Research] Scientists investigated whether cell inflammation could worsen after exposure to A. fumigatus spores in vitro and then, in mice, following chronic exposure to cigarette smoke mimicking chronic obstructive pulmonary disease.
Anemonin Suppresses Sepsis-Induced Acute Lung Injury by Inactivation of Nuclear Factor-Kappa B and Activation of Nuclear Factor Erythroid 2-Related Factor-2/Heme Oxygenase-1 Pathway
[FASEB Journal] To identify whether anemonin had protective effects on sepsis-induced acute lung injury (ALI), a mouse sepsis-induced ALI model and cellular models using the mouse alveolar macrophage MH-S cells and mouse lung epithelial MLE-12 cells were established.
Circulating Tumor DNA in Early Stage and Locally Advanced NSCLC: Ready for Clinical Implementation?
[Nature Reviews Clinical Oncology] Researchers summarize the increasing evidence suggesting that circulating tumor DNA has potential clinical applications in the management of patients with early stage and locally advanced NSCLC.
Secondhand Vape Exposure Regulation of CFTR and Immune Function in Cystic Fibrosis
[American Journal of Physiology-Lung Cellular and Molecular Physiology] Human cystic fibrosis (CF) and non-CF blood monocyte derived macrophages and bronchial epithelial cells were exposed to flavored and unflavored e-cigs.
Parenchymal and Inflammatory Responses to Ozone Exposure in the Aging Healthy and Surfactant Protein C Mutant Lung
[American Journal of Physiology-Lung Cellular and Molecular Physiology] Flow cytometric analysis revealed increases in mononuclear myeloid abundance in aged SP-C mutant lungs, paired with a contraction in CD8+ expressing cells.
Innovent and ASK Pharm Jointly Announce NMPA Approval of Limertinib, a Third-generation EGFR TKI for the Treatment of Lung Cancer
[Innovent Biologics, Inc. (PR Newswire)] Innovent Biologics, Inc. and Jiangsu Aosaikang Pharmaceutical Co. Ltd. jointly announced that China's National Medical Products Administration (NMPA) has approved the New Drug Application of limertinib for the treatment of adult patients with locally advanced or metastatic EGFR T790M-mutated NSCLC.
Molecular Characterization of EBV-Associated Primary Pulmonary Lymphoepithelial Carcinoma by Multiomics Analysis
[BMC Cancer] The authors explored primary pulmonary lymphoepithelial carcinoma using whole-exome sequencing and RNA-whole-transcriptome sequencing technologies.
A Novel Human Fetal Lung-Derived Alveolar Organoid Model Reveals Mechanisms of Surfactant Protein C Maturation Relevant to Interstitial Lung Disease
[EMBO Journal] Researchers described the development of mature, expandable alveolar type 2 (AT2) organoids derived from human fetal lungs which were phenotypically stable, could differentiate into AT1-like cells, and were genetically manipulable.
Longitudinal Single-Cell Profiles of Lung Regeneration after Viral Infection Reveal Persistent Injury-Associated Cell States
[Cell Stem Cell] Using single-cell transcriptomics combined with lineage tracing of proliferating progenitors, investigators examined mouse lung regeneration after influenza injury, demonstrating an asynchronously phased response across different cellular compartments.
PLAC8 Attenuates Pulmonary Fibrosis and Inhibits Apoptosis of Alveolar Epithelial Cells via Facilitating Autophagy
[Communications Biology] The authors found that PLAC8 was downregulated in the lungs of idopathic pulmonary fibrosis patients, in bleomycin-induced lungs of mice, and in primary murine alveolar epithelial type II cells and human lung epithelial cell A549 cells.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
