Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
MACC1 Ablation Suppresses the Dedifferentiation Process of Non-CSCs in Lung Cancer Through Stabilizing KLF4
[Cell Death Discovery] The authors showed that metastasis-associated in colon cancer-1 (MACC1) promoted the transition from non-cancer stem cell (CSC) to CSC in lung cancer.
Overexpression of ELF3 in the PTEN-Deficient Lung Epithelium Promotes Lung Cancer Development by Inhibiting Ferroptosis
[Cell Death & Disease] Scientists showed that the synergistic role of ELF3 overexpression and PTEN deficiency in driving lung cancer development was highly dependent on the regulation of ferroptosis.
Downregulation of tRNA Methyltransferase FTSJ1 by PM2.5 Promotes Glycolysis and Malignancy of NSCLC via Facilitating PGK1 Expression and Translation
[Cell Death & Disease] Scientists revealed a previously unrecognized function of fine particulate matter (PM2.5)-downregulated FTSJ1 on phosphoglycerate kinase 1 (PGK1) -mediated glycolysis in NSCLC.
Longitudinal Blood Immune-Inflammatory and Radiomic Profiling to Decode Different Patterns of Acquired Resistance to Immunotherapy in Patients with NSCLC
[Clinical Cancer Research] Investigators explored whether distinctive clinico-pathological, radiomic and peripheral blood immune-inflammatory features reflected oligo- and systemic-acquired resistance in advanced NSCLC patients undergoing immune checkpoints inhibitors.
An Injury-Induced Mesenchymal-Epithelial Cell Niche Coordinates Regenerative Responses in the Lung
[Science] Scientists used lineage tracing and temporal single-cell RNA-sequencing to characterize and profile alveolar Pdgfra+ and Pdgfrb+ fibroblast cells after multiple modes of acute lung injury.
Loss of Fbxo45 in AT2 Cells Leads to Insufficient Histone Supply and Initiates Lung Adenocarcinoma
[Cell Death & Differentiation] Scientists demonstrated that knockout of Fbxo45 in mouse alveolar epithelial type 2 cells led to spontaneous lung adenocarcinoma. They revealed that FBXO45 was a novel cell-cycle-regulated protein that was degraded upon phosphorylation by CDK1 during the S/G2 phase.
TFF3 Drives Hippo Dependent EGFR-TKI Resistance in Lung Adenocarcinoma
[Oncogene] The authors observed that trefoil factor 3 (TFF3) was a crucial mediator of the lung adenocarcinoma (LUAD) epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) response. TFF3 conferred intrinsic resistance to EGFR inhibition in LUAD by promotion of EGFR activation.
Morphogenesis and Regeneration Share a Conserved Core Transition Cell State Program That Controls Lung Epithelial Cell Fate
[Developmental Cell] The authors identified a population of Icam1/Nkx2-1 epithelial progenitors harboring a transitional state program remarkably conserved in humans and mice during lung morphogenesis and regeneration.
Lurbinectedin Sensitizes PD-L1 Blockade Therapy by Activating STING-IFN Signaling in Small-Cell Lung Cancer
[Cell Reports Medicine] Scientists demonstrated that lurbinectedin treatment activated the STING pathway, which increased interferon (IFN) signaling, pro-inflammatory chemokines, and major histocompatibility complex class I in small-cell lung cancer models.
CXCR1+ Neutrophil Infiltration Orchestrates Response to Third-Generation EGFR-TKI in EGFR Mutant Non-Small-Cell Lung Cancer
[Signal Transduction and Targeted Therapy] The authors integrated scRNA sequencing, bulk RNA sequencing, multiplexed immunofluorescence, and flow cytometry data from pretreatment and post-resistant tumor samples of EGFR-mutant NSCLC patients received third-generation epidermal growth factor receptor—tyrosine kinase inhibitors (EGFR-TKIs).
A Review of the Complex Interplay between Chemoresistance and lncRNAs in Lung Cancer
[Journal of Translational Medicine] Investigators discuss the complex relationship between lncRNAs and drug resistance in LC, particularly through exosomal pathways, and the development of innovative therapeutic strategies to enhance drug efficacy by targeting lncRNAs.
A STAG2-PAXIP1/PAGR1 Axis Suppresses Lung Tumorigenesis
[Journal of Experimental Medicine] Scientists coupled somatic CRISPR-Cas9 genome editing and tumor barcoding with an autochthonous oncogenic KRAS-driven lung cancer model and showed that STAG2 was uniquely tumor-suppressive among all core and auxiliary cohesin components.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
