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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Mechanistic Insights and Approaches for Beta Cell Regeneration
[Nature Chemical Biology] The authors summarize recent chemical biology breakthroughs advancing the knowledge of beta cell regeneration. They present current chemical-based tools, sensors, and mechanistic insights into pathways that can be targeted to enhance beta cell regeneration in model organisms.
Gemcitabine and ATR Inhibitors Synergize to Kill PDAC Cells by Blocking DNA Damage Response
[Molecular Systems Biology] Investigators phenotypically screened 13 human PDAC cell lines against gemcitabine in combination with 146 clinical inhibitors and observed strong synergy for the ATR kinase inhibitor elimusertib in most cell lines.
Targeting Pancreatic Cancer Glutamine Dependency Confers Vulnerability to GPX4-Dependent Ferroptosis
[Cell Reports Medicine] The authors elucidated that prolonged glutamine (Gln) restriction or treatment with the Gln antagonist, 6-diazo-5-oxo-L-norleucine, led to growth inhibition and ferroptosis program activation in PDAC.
S100A13-Driven Interaction Between Pancreatic Adenocarcinoma Cells and Cancer-Associated Fibroblasts Promotes Tumor Progression through Calcium Signaling
[Cell Communication and Signaling] Bioinformatic analysis was employed to predict the pathogenic potential of cancer-associated fibroblasts (CAFs) and S100A13. Stable S100A13 knockdown CAFs were generated using a short hairpin RNA system.
Hypusinated and Unhypusinated Isoforms of the Translation Factor eIF5A Exert Distinct Effects in Models of Pancreas Development and Function
[Journal of Biological Chemistry] Scientists utilized zebrafish and mouse models with inducible knockdowns of deoxyhypusine synthase and eukaryotic translation initiation factor 5A (eIF5A) to investigate their roles in cellular growth.
Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
[Cancer Research] Scientists found that terminal uridylyltransferase 1 (TUT1) was required for the survival of PDAC cells but not for normal pancreatic cells.
The GLP-1R Agonist Semaglutide Reshapes Pancreatic Cancer Associated Fibroblasts Reducing Collagen Proline Hydroxylation and Favoring T Lymphocyte Infiltration
[Journal of Experimental & Clinical Cancer Research] Scientists investigated the effect of dysmetabolism on pancreatic ductal adenocarcinoma (PDAC) development in a pre-clinical PDAC model with a specific focus on the stromal compartment.
Adjuvant Chemotherapy after Resection of Localized Pancreatic Adenocarcinoma following Preoperative FOLFIRINOX
[Jama Oncology] This retrospective cohort study included patients with localized PDAC treated with 2 to 11 cycles of preoperative (m)FOLFIRINOX (combination leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin in full or modified dosing) followed by resection.
SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer
[Cancer Research] Investigators used single-cell RNA-sequencing to analyze the cellular landscape of Trp53-mutant mouse models driven by KrasG12D or KrasG12V in which Smad4 was wild-type or deleted.
Lineage Tracing of Pancreatic Cells for Mechanistic and Therapeutic Insights
[Trends In Endocrinology and Metabolism] Scientists summarize advances, challenges, and future directions in tracing pancreatic cell origins and fates using lineage-tracing technologies.
Betagenin Ameliorates Diabetes by Inducing Insulin Secretion and β-Cell Proliferation
[Journal of Biological Chemistry] Researchers isolated and identified a new intestine-derived hormone, betagenin, and showed that it stimulated insulin secretion and β-cell proliferation and suppresses β-cell apoptosis.
Targeting uPAR with An Antibody-Drug Conjugate Suppresses Tumor Growth And Reshapes The Immune Landscape In Pancreatic Cancer Models
[Science Advances] The authors explored the urokinase plasminogen activator receptor (uPAR) as a candidate antibody-drug conjugate target in PDAC, harnessing its massive tumoral and stromal expression in this stroma-dense tumor.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
