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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Matrix Viscoelasticity Controls Differentiation of Human Blood Vessel Organoids into Arterioles and Promotes Neovascularization in Myocardial Infarction
[Advanced Materials] The hypothesis that matrix viscoelasticity regulates vascular development was investigated in 3D cultures by encapsulating blood vessel organoids within viscoelastic gelatin/β-CD assembly dynamic hydrogels or methacryloyl gelatin non-dynamic hydrogels.
Collagen Signaling and Matrix Stiffness Regulate Multipotency in Glandular Epithelial Stem Cells in Mice
[Nature Communications] Researchers found that Collagen I expression was commonly upregulated in adult basal stem cells (BaSCs) across the different multipotent conditions. Increasing collagen concentration or stiffness of the ECM promoted BaSC multipotency in mammary gland and prostate organoids.
Functional Heterogeneity of Fibroblasts in Primary Tumors and Metastases
[Trends in Cancer] With the aim of bridging cancer-associated fibroblasts (CAF) molecular and functional heterogeneity, the authors focus on recently identified functional interactions of CAF subtypes with malignant cells, immune cells, and other stromal cells in primary tumors and metastases.
Application of Adipose Extracellular Matrix and Reduced Graphene Oxide Nanocomposites for Spinal Cord Injury Repair
[Advanced Healthcare Materials] Pristine adipose tissue-derived ECM (adECM) and adECM-reduced graphene oxide nanocomposites were implanted directly after hemisection spinal cord injury in rats. Compared to pristine adECM, adECM-rGO nanocomposites completely restord spinal cord integrity.
High-Throughput Formulation of Reproducible 3D Cancer Microenvironments for Drug Testing in Myeloid Leukemia
[Biofabrication] Scientists used droplet microfluidics to co-encapsulate human chronic myeloid leukemia cancer cells and widely utilized stromal bone marrow cells inside hydrogel microbeads and demonstrate their use as miniature, highly reproducible 3D models of the leukemic bone-marrow microenvironment and leukemia–stroma crosstalk.
Nascent Matrix Deposition Supports Alveolar Organoid Formation from Aggregates in Synthetic Hydrogels
[Stem Cell Reports] Scientists developed a two-step culture method that involved pre-aggregation of organoids in hydrogel-based microwells followed by embedding in a synthetic hydrogel that supported alveolar organoid growth, while also offering considerable control over organoid and hydrogel properties.
New Insights into the Structural Role of EMILINs Within the Human Skin Microenvironment
[Scientific Reports] Scientists investigated the spatiotemporal localization of elastin microfibril interface-located proteins (EMILIN) -1, -2, and -3 in human skin induced by aging, UV-exposure, fibrosis, and connective tissue disorder.
Native DGC Structure Rationalizes Muscular Dystrophy-Causing Mutations
[Nature] An unexpected β-helix comprising β-, γ- and δ-sarcoglycan formed an extracellular platform that interacted with α-dystroglycan, β-dystroglycan and α-sarcoglycan, allowing α-dystroglycan to contact the extracellular matrix.
Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies
[Advanced Science] The authors discuss organ-specific molecular mechanisms of fibrosis, including cardiac fibrosis, hepatic fibrosis, renal fibrosis, and pulmonary fibrosis.
Substrate Stiffness Regulates the Proliferation and Inflammation of Chondrocytes and Macrophages Through Exosomes
[Acta Biomaterialia] Using tunable stiffness Gelatin methacryloyl hydrogel, the authors demonstrated that a potential optimal substrate stiffness could promote maximal chondrocyte proliferation and exosome secretion.
Enhancing Vaginal Reconstruction through 3D Bioprinted Scaffolds Using a Novel vECM-GelMA-SF Bioink
[Biofabrication] Researchers developed a unique bioink composed of porcine vaginal ECM, gelatin methacrylamide, and silk fibroin to facilitate the bioprinting of a vaginal scaffold. This bioink is suitable for constructing 3D bioprinted vaginal scaffolds of various dimensions.
Microvilli Control the Morphogenesis of the Tectorial Membrane Extracellular Matrix
[Developmental Cell] Scientist identified that α-tectorin was released by distinct modes: proteolytic shedding by TMPRSS2 and GPI-anchor-dependent release from the microvillus tip in mice.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
