Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

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NINJ1-Mediated Plasma Membrane Rupture of Pyroptotic Endothelial Cells Exacerbates Blood-Brain Barrier Destruction Caused by Neutrophil Extracellular Traps in Traumatic Brain Injury

February 20, 2025

[Cell Death Discovery] Excessive neutrophil extracellular traps (NETs) were found in both contused brain tissue and circulation following traumatic brain injury (TBI). Investigators found that NETs could activate the TLR4/NF-κB pathway to induce brain endothelial cell pyroptosis.

Lymphatic Transport in Anti-Tumor Immunity and Metastasis

February 19, 2025

[Journal of Experimental Medicine] Investigators review the involvement of lymphatic vessels s in tumor progression, metastasis, and modulation of anti-tumor immune response.

Urolithin A Enhances Tight Junction Protein Expression in Endothelial Cells Cultured In Vitro via Pink1-Parkin-Mediated Mitophagy in Irradiated Astrocytes

February 18, 2025

[Journal of Molecular Neuroscience] The authors suggested that irradiation activated astrocytes with altered polarity, generating both cellular and mitochondrial reactive oxygen species.

Tropisetron Attenuates High-Glucose-Induced Vascular Endothelial Dysfunction via Inhibition of Calcineurin/NFAT Signaling

February 18, 2025

[European Journal of Pharmacology] Researchers investigated the effects of tropisetron, a calcineurin inhibitor, on high glucose-induced hypertrophy and apoptosis in HUVECs.

Screening of Homing and Tissue-Penetrating Peptides by Microdialysis and In Vivo Phage Display

February 14, 2025

[Life Science Alliance] Scientists combined in vivo phage display with microdialysis-based parenchymal recovery and high-throughput sequencing to select for peptides that, besides vascular homing, facilitate extravasation and tissue penetration.

Endothelial Monocarboxylate Transporter 1 Drives Atherosclerosis via a Lactate/NADH/CtBP-Mediated Transrepression Pathway

February 14, 2025

[MedComm] Investigators demonstrated that lactate accumulation in aortic tissues and blood was correlated with increased monocarboxylate transporter 1 (Mct1) expression in endothelial cells within atherosclerotic plaques.

Scavenger Endothelial Cells Alleviate Tissue Damage by Engulfing Toxic Molecules Derived from Hemolysis

February 13, 2025

[Proceedings of The National Academy of Sciences of The United States of America] In zebrafish, the authors found that scavenger endothelial cells engulfed both macromolecular hemoglobin and small molecular unconjugated bilirubin, two primary toxic byproducts of hemolysis.

Promoting the Transition from Pyroptosis to Apoptosis in Endothelial Cells: A Novel Approach to Alleviate Methylglyoxal-Induced Vascular Damage

February 13, 2025

[Journal of Translational Medicine] HUVECs were used for in vitro experiments. Cell death modes were assessed through morphological observations. Mechanistic investigations were performed using immunofluorescence, flow cytometry, Western blotting, and ELISA.

Endothelial-Specific Postnatal Deletion of Nos3 Preserves Intraocular Pressure Homeostasis via Macrophage Recruitment and NOS2 Upregulation

February 12, 2025

[Journal of Clinical Investigation] Researchers studied the effects of a conditional, endothelial-specific postnatal deletion of nitric oxide synthase-3 (Nos3) on tissues of the outflow pathway.

Endothelial Insulin Resistance Induced by Adrenomedullin Mediates Obesity-Associated Diabetes

February 11, 2025

[Science] The authors discovered that adrenomedullin, a peptide hormone that increased in concentration in the setting of obesity, inhibited insulin signaling in the endothelium of both humans and mice.

MT2A Promotes Angiogenesis in Chronically Ischemic Brains through a Copper–Mitochondria Regulatory Mechanism

February 7, 2025

[Journal of Translational Medicine] The authors collected dura matter samples from chronic ischemic cerebrovascular disease patients and examined the expression of cuproptosis-related genes to confirm the inhibitory effect of copper overload on angiogenesis.

Loss of Endothelial TRPC1 Induces Aortic Hypercontractility and Hypertension

February 6, 2025

[Circulation Research] The authors generated endothelial-specific transient receptor potential channel canonical family member 1 (TRPC1)-deficient and knockin mice and analyzed their changes in vascular function under physiological and pathologically obese state.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.