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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Bilayered Skin Equivalent Mimicking Psoriasis as Predictive Tool for Preclinical Treatment Studies
[Communications Biology] Scientists focused on treatment responses of 3D skin replicas. Cytokine-priming of skin organoids induced psoriatic features like inflammation, antimicrobial peptides, hyperproliferation, and impaired differentiation.
Mechanistic Basis of Atypical TERT Promoter Mutations
[Nature Communications] Atypical telomerase reverse transcriptase promoter (TERTp) mutations occured with canonical driver mutations in large cancer cohorts and arose subclonally specifically on the TERTp driver mutant chromosome homolog of melanoma cells treated with UV light in vitro.
Deciphering Melanophagy: Role of the PTK2-ITCH-MLANA-OPTN Cascade on Melanophagy in Melanocytes
[Autophagy] The authors discovered a regulatory signaling cascade that controlled melanophagy in 3,4,5-trimethoxycinnamate thymol ester (TCTE)-treated melanocytes. They highlight role of the protein tyrosine kinase 2 (PTK2)-itchy E3 ubiquitin protein ligase (ITCH)-melan-A (MLANA)-optineurin (OPTN) cascade in orchestrating melanophagy progression.
Unveiling the Impact of Hypodermis on Gene Expression for Advancing Bioprinted Full-Thickness 3D Skin Models
[Communications Biology] Researchers leveraged 3D bioprinting technology to fabricate a full-thickness human skin equivalent with hypodermis. The collagen hydrogel-based structure provided a mimetic environment for skin cells to adhere, proliferate, and differentiate.
TIPE2 Inhibits Melanoma Progression Through MEK/ERK Signaling
[Scientific Reports] This study elucidated the mechanism of action of TNFAIP8-like 2 (TIPE2) in the development of melanoma. Overexpression of TIPE2 inhibited the proliferation of melanoma cells in vitro and even inhibited tumor formation in vivo.
Molecular Mechanisms of MAZ Targeting Up-Regulation of NDUFS3 Expression to Promote Malignant Progression in Melanoma
[Communications Biology] Investigators found that Myc-associated zinc-finger protein (MAZ) could target and regulate the transcription of NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 (NDUFS3), a core subunit of mitochondrial complex I, to enhance mitochondrial metabolism and thus promote malignant progression of melanoma.
Three Researchers at Uppsala University Receive ERC Synergy Grants
[Uppsala University] Three researchers at Uppsala University have been awarded European Research Council (ERC) Synergy Grants in the 2024 call. Their work wil help to develop and improve immunotherapy for the treatment of glioblastoma and malignant melanoma cancers.
Cancer-Associated Fibroblast Subtypes Modulate the Tumor-Immune Microenvironment and Are Associated with Skin Cancer Malignancy
[Nature Communications] This study dissected the intra-tumoral diversity of cancer-associated fibroblasts in basal cell carcinoma, squamous cell carcinoma, and melanoma using molecular and spatial single-cell analysis.
Concurrent SOS1 and MEK Suppression Inhibits Signaling and Growth of NF1-Null Melanoma
[Cell Reports Medicine] Using biochemical and pharmacological assays on patient-derived models and isogenic cell lines, scientists revealed that neurofibromin (NF1)-null melanomas were dependent on RAS activation and that MEK inhibition relieved ERK-dependent negative feedback, increasing RAS signaling.
Nuclear Versus Cytoplasmic IKKα Signaling in Keratinocytes Leads to Opposite Skin Phenotypes and Inflammatory Responses, and a Different Predisposition to Cancer
[Oncogene] Researchers demonstrated that at each subcellular localization, IKKα differently regulated signaling pathways important for maintaining the balance between keratinocyte proliferation and differentiation, and for the cutaneous inflammatory response.
Transcriptomic Analysis of Melanoma Cells Reveals an Association of α-Synuclein with Regulation of the Inflammatory Response
[Scientific Reports] Scientists conducted a comparative RNA-seq analysis of human SK-MEL-28 melanoma cells and several SK-MEL-28 SNCA-KO clones to uncover genes/pathways influenced by alpha-synuclein.
Pooled Long-Term Outcomes with Nivolumab plus Ipilimumab or Nivolumab Alone in Patients with Advanced Melanoma
[Journal of Clinical Oncology] In this large, pooled, nonrandomized, retrospective analysis, scientists observed that nivolumab (NIVO) + ipilimumab provided longer overall survival than NIVO in patients with immune checkpoint inhibitor treatment–naïve advanced melanoma.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
