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Cell Therapy News
Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
Efficacy and Safety of Anti–B-Cell Maturation Antigen Chimeric Antigen Receptor T-Cell for the Treatment of Relapsed and Refractory AL Amyloidosis
[Journal of Clinical Oncology] This largest clinical trial of AL amyloidosis patients treated with anti-BCMA CART demonstrates acceptable and manageable toxicity in a highly frail and resistant population with remarkable efficacy, leading to fast organ responses.
CAR T Cells Secreting NGF-Neutralizing scFv Enhance Efficacy in Clear Cell Renal Cell Carcinoma by Relieving Immunosuppression through Immunosympathectomy
[Journal for ImmunoTherapy of Cancer] Researchers screened for sympathetic gene sets in various types of cancers and investigated the association of sympathetic nerves with immunosuppression in renal clear cell carcinoma.
An Erythroid-Specific Lentiviral Vector Improves Anemia and Iron Metabolism in a New Model of XLSA
[Blood] Researchers engineered a conditional Alas2-KO mouse model using tamoxifen administration or treatment with lipid nanoparticles carrying Cre-mRNA and conjugated to an anti-CD117 antibody.
Co-Infusion of Mesenchymal Stromal Cells to Prevent GVHD After Allogeneic Hematopoietic Cell Transplantation from HLA-Mismatched Unrelated Donors After Reduced-Intensity Conditioning: A Double-Blind Randomized Study...
[Stem Cell Research & Therapy] Scientists established a multicenter, prospective, randomized, double-blind trial evaluating the efficacy of co-infusing third-party mesenchymal stromal cells versus placebo on the day of hematopoietic stem cell transplantation to prevent graft-versus-host disease (GVHD) in recipients of HLA-mismatched unrelated donors after reduced-intensity conditioning.
Placental Nanoparticle-Mediated IGF1 Gene Therapy Corrects Fetal Growth Restriction in a Guinea Pig Model
[Gene Therapy] Researchers showed efficacy of repeated treatments of trophoblast-specific human insulin-like 1 growth factor gene therapy delivered in a non-viral, polymer nanoparticle to the placenta for the treatment of fetal growth restriction.
Antiviral Potential of Vδ2 T-Cells in Children Given TCR αβ/CD19 Cell Depleted HLA-Haploidentical HSCT
[Blood Advances] Scientists investigated the antiviral protective profile of Vδ2 T cells in pediatric patients given this type of allograft. The characterization of γδ T cells was performed by flow cytometry in haplo-HSCT-pediatric patients in the donor graft and after 30, 60 and 120 days post-HSCT.
Bispecific Antibodies Targeting BCMA or GPRC5D Are Highly Effective in Relapsed Myeloma after CAR T-Cell Therapy
[Blood Cancer Journal] The authors analyzed outcomes of post-CAR T-cell therapy relapse and impact of different salvage strategies in an international cohort of 139 patients, receiving talquetamab, teclistamab, combinations of immunomodulating drugs, proteasome inhibitors or CD38 monoclonal antibodies, and others.
A Chimeric Peptide Promotes Immune Surveillance of Senescent Cells in Injury, Fibrosis, Tumorigenesis, and Aging
[Nature Aging] Researchers employed a chimeric peptide as a ‘matchmaker’ to bind to the urokinase-type plasminogen activator receptor, a cell surface marker of senescent cells.
Impact of T Cell Characteristics on CAR-T Cell Therapy in Hematological Malignancies
[Blood Cancer Journal] Investigators review progressing research on T cell characteristics that impact the effectiveness of CAR-T cells, including T cell exhaustion, memory subsets, senescence, regulatory T cells, the CD4+ to CD8+ T cell ratio, metabolism, and the T cell receptor repertoire.
Silencing Hepatic PCSK9 via Novel Chimeric AAV8 Vectors Mitigates the Progression of Atherosclerosis by Inhibiting Inflammation in ApoE-/- Mice
[Molecular Therapy-Methods & Clinical Development] Scientists developed a novel chimeric AAV8.P-proprotein convertase subtilisin/kexin type 9 (PCSK9) shRNA vector that incorporated a cross-species specific short hairpin RNA targeting PCSK9 to assess its effects on lipid levels and atherosclerosis in mice.
Increased Functional Potency of Multi-Edited CAR-T Cells Manufactured by a Non-Viral Transfection System
[Molecular Therapy-Methods & Clinical Development] Investigators reported that Solupore®, a GMP aligned, non-viral physicochemical transfection system, could be used to manufacture multi-edited CAR-T cells using CRISPR Cas9 RNPs while maintaining robust cell functionality.
Synthetic Mismatches Enable Specific CRISPR-Cas12a-Based Detection of Genome-Wide SNVs Tracked by ARTEMIS
[Cell Reports Methods] The authors presented an in silico pipeline that scanned the human genome for targeting pathogenic mutations in the seed region (ARTEMIS), the most stringent CRISPR RNA domain.
Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
