Newsletters

[Advanced Materials] The hypothesis that matrix viscoelasticity regulates vascular development was investigated in 3D cultures by encapsulating blood vessel organoids within viscoelastic gelatin/β-CD assembly dynamic hydrogels or methacryloyl gelatin non-dynamic hydrogels.

[Nature Communications] Researchers found that Collagen I expression was commonly upregulated in adult basal stem cells (BaSCs) across the different multipotent conditions. Increasing collagen concentration or stiffness of the ECM promoted BaSC multipotency in mammary gland and prostate organoids.

[Signal Transduction and Targeted Therapy] The randomized Phase III CHART trial revealed that rezvilutamide plus androgen deprivation therapy in high-volume, metastatic, hormone-sensitive prostate cancer significantly enhanced radiographic progression-free and overall survival than bicalutamide.

[Journal of Clinical Investigation] NEDD4L expression was significantly inhibited in intestinal epithelial cells (IECs) of patients with Crohn's disease, ulcerative colitis, and colorectal cancer. Global knockout of NEDD4L or its deficiency in IECs exacerbated dextran sulfate sodium (DSS)-/2,4,6-trinitrobenzene sulfonic acid-induced colitis and azoxymethane/DSS-induced colorectal cancer.

[Nature Reviews Neurology] The authors discuss how microglia, monocytes, and T cells contribute to the pathogenesis of MS, Alzheimer's disease, ALS, and Parkinson disease, and their potential as shared therapeutic targets across these diseases.

[Development] Scientists investigated how levels of ASCL1 and its phosphorylation modulated its activity over progressive lineage restriction of mouse embryonic stem cells.

[Journal of Clinical Investigation] Upon induction of Ecotropic viral integration site 1 (Evi1) expression, mice displayed anemia, thrombocytopenia, lymphopenia, and erythroid and megakaryocyte dysplasia with a significant expansion of committed myeloid progenitor cells, resembling human myelodysplastic syndrome/myeloproliferative neoplasm–like disease.

[Experimental Hematology] It's safe to say that iPSC models are a mainstay of leukemia modeling “toolbox” alongside primary human cells from normal and patient sources. The authors discuss the rationale, history, challenges, and recent advances of iPSC models for modeling myeloid neoplasms.

[Cell Reports] Researchers identified that the interleukin-22 receptor subunit alpha 1 (IL-22RA1), known as a co-receptor for IL-22, was downregulated in human and mouse type 2 diabetes β cells.

[Journal of Clinical Oncology] Researchers presented 10-year results of the Phase III FOWARC trial, which evaluated the efficacy of modified infusional fluorouracil, leucovorin, and oxaliplatin with or without radiation compared with fluorouracil with radiation in patients with locally advanced rectal cancer.

[Cancer Gene Therapy] Investigators found that integrin subunit alpha 3 (ITGA3) expression was elevated in pancreatic cancer tissues and predicted poor prognosis for patients with pancreatic cancer.

[Oncogene] Genetic deletion and pharmacological inhibition of the main chaperone of the mitochondrial unfolded protein response heat shock protein 60 reduced neuroendocrine prostate cancer (NEPC) growth in vivo as well as reverted NEPC cells to a more epithelial-like state.