Newsletters

[Communications Biology] Scientists focused on treatment responses of 3D skin replicas. Cytokine-priming of skin organoids induced psoriatic features like inflammation, antimicrobial peptides, hyperproliferation, and impaired differentiation.

[Nature Communications] Atypical telomerase reverse transcriptase promoter (TERTp) mutations occured with canonical driver mutations in large cancer cohorts and arose subclonally specifically on the TERTp driver mutant chromosome homolog of melanoma cells treated with UV light in vitro.

[Communications Biology] Using single-cell RNA sequencing, researchers generated a comprehensive molecular atlas, describing human pancreatic organoids derived from human islet-depleted pancreatic tissue.

[Molecular Psychiatry] Researchers found that amyloid precursor protein (APP)V225A mutation altered the N-terminal structure of APP, which enhanced its binding affinity to tau protein and significantly increased APP-mediated endocytosis.

[Nature Reviews Nephrology] A wide range of therapeutics are in development for collagen and kidney disorders, including genetic approaches, chaperone therapies, protein degradation strategies, and anti-fibrotic therapies.

[Nature Cancer] Researchers used 6,193 whole-genome sequenced tumors to study the contributions of transcription and DNA replication collisions to genome instability. Large tandem duplications were abundant in female-enriched, upper gastrointestinal tract, and prostate cancers.

[Nature Communications] The authors presented a comprehensive transcriptomic landscape of the prostate tumor microenvironment at multiple points in the standard treatment timeline employing single-cell RNA-sequencing and spatial transcriptomics data from 120 patients.

[Molecular Cancer Research] The authors showed that the expression of pyroptosis-associated proteins was greater in the endothelial cells of metastatic nasopharyngeal carcinoma tissues than in those of nontumor tissues.

[Stem Cell Research & Therapy] Endothelial progenitor cell-derived conditioned medium was analyzed by cytokine array to identify key factors involved in angiogenesis and cellular senescence.

[Cell Death Discovery] Researchers constructed GLS2−/−ApoE−/− mice by using HBLV-GLS2 shRNA injection. Immunofluorescence, western blotting, transmission electron microscopy were applied to detect profiles of endothelial injury and atherosclerosis progression.

[Scientific Reports] Scientists investigated whether Catalpol regulated apoptosis and proliferation following vascular injury induced by burns using an in vitro model of oxygen-glucose deprivation with a HUVEC line.

[Scientific Reports] Researchers investigated the impact of Houshiheisan-modified xtracellular vesicles-derived extracellular vesicles on angiogenesis using rats with permanent middle cerebral artery occlusion and brain microvascular endothelial cells subjected to oxygen-glucose deprivation.