Newsletters

[Science Advances] Scientists identified transient receptor potential melastatin 7 (TRPM7), an Mg²⁺-permeable ion channel, as a critical regulator of muscle stem cell activation.

[Blood Cancer Journal] Investigators retrospectively analyzed 283 adults treated with commercial CD19 CAR-T therapy, assessing 958 PET-CT scans across four time points: pre-apheresis, pre-lymphodepletion, best response, and relapse.

[Nature Neuroscience] Researchers tested between a serial model and a parallel model by asking how schema correlated in rat orbitofrontal cortex would be affected by inactivating the output of the hippocampus, after learning and during transfer across problems.

[Cell Death & Disease] Scientists used mice of Elane-knockout and wild-type, and their primary mouse hepatocytes to establish metabolic-associated fatty liver disease (MAFLD) models in vivo and in vitro for elucidating the role of Elane in ferroptosis of hepatocytes and MAFLD development.

[Science Advances] Scientists identified transient receptor potential melastatin 7 (TRPM7), an Mg²⁺-permeable ion channel, as a critical regulator of muscle stem cell activation.

[Biocon Biologics] Biocon Biologics announced that the US FDA has approved Jobevne^™, a biosimilar Bevacizumab for intravenous use. JOBEVNE is a VEGF inhibitor that binds with VEGF and blocks the interaction with its receptors to prevent angiogenesis.

[NexThera Co., Ltd. (BioSpace)] NexThera Co., Ltd. announced that it has completed the first patient enrollment for its Phase I/IIa clinical trial of NT-101, a novel eye drop treatment for wet AMD, at a clinical trial site in Pennsylvania.

[Nature Communications] Scientists investigated the mechanisms of blood-brain barrier traversal by T. gondii and T. gondii-infected leukocytes, using intracarotid arterial delivery into the cerebral circulation of mice.

[NPJ Precision Oncology] Researchers constructed a single-cell atlas of endothelial cells (ECs) using single-cell transcriptomic data. It was found that tip-like ECs were abundant in the primary tumors and metastatic foci.

[Oncogene] Investigators revealed that FLT1-enriched extracellular vesicles induced a positive feedback loop between nasopharyngeal carcinoma cells and endothelial cells to promote tumor angiogenesis and tumor metastasis.

[Cell Death Discovery] Researchers conducted a comparative gene expression analysis of several in vitro and in vivo models and identified galectin-3 as a potential biomarker of the disease.

[King's College London] Dr Robert Seaborne and Dr Simon Cleary have been awarded grants from The Academy of Medical Sciences through the Springboard scheme, which supports outstanding biomedical research.