[Signal Transduction and Targeted Therapy] Scientists designed chikungunya virus (CHIKV) mRNA vaccines containing full-length structural proteins or part of structural proteins based on conserved sequences from 769 viral strains encompassing four lineages.

[EMBO Journal] Researchers showed that T-bet+ cells induced by lymphocytic choriomeningitis virus infection encompassed a TH1 cell subset expressing granzyme B and a Tcf-1+ cell subset that retained the potential for T follicular helper (TFH) differentiation without expressing mature TFH markers.

[Nature Immunology] Scientists analyzed hundreds of cellular and molecular features in the context of discrete pulmonary phenotypes to define the systemic immune landscape of post-COVID lung disease.

[Nature] Investigators described the identification of JNJ-9676, a small-molecule inhibitor targeting the coronavirus M protein.

[Experimental & Molecular Medicine] Scientists describe the most current knowledge regarding the innate immune response to hepatitis A virus (HAV) and the HAV-mediated counteractions against innate immune responses.

[Blood] Using human isogenic iPSC-based models of SRSF2-mutant myelodysplastic syndromes (MDS) and primary MDS patient cells, scientists showed that the SRSF2 P95L mutation downregulated basal STAT1 expression.

[Nucleic Acids Research] Researchers generated two human pluripotent cell models containing a single functional DGCR8 allele to elucidate its role in early development.

[Nature Structural & Molecular Biology] Scientists showed that deletion of the Ogt gene in mESC results in a widespread increase in the TET product 5-hydroxymethylcytosine in both euchromatic and heterochromatic compartments, with a concomitant reduction in the TET substrate 5-methylcytosine at the same genomic regions.

[EMBO Journal] Using a hPSC model, researchers deciphered cardiac and non-cardiac lineage trajectories in differentiation and identified transcription factors underpinning cell specification, identity, and function.

[Stem Cells Translational Medicine] hESCs were used to test the hypothesis that 6.4-640 nM and 19.2-192 µM menthol, which activates transient-receptor-potential (TRP) channels, altered calcium homeostasis in embryos and adversely affected processes that are critical to gastrulation.

[PLOS One] When researchers investigated the cell type composition of gastruloids grown from different pre-cultures, they observed that mESCs subjected to 2i-ESLIF preceding aggregation generated gastruloids more consistently, including more complex mesodermal contributions than the ESLIF-only control.

[Toxicology Research] Investigators showed that bisphenol A at doses of 1–2 μmol/L triggered apoptotic processes without necrotic cell death in the ESC-B5 mouse ESC line.