[Keck Medicine USC] Keck Medicine of University of Southern California (USC) is participating in a national, multisite clinical trial examining if a water vapor system that uses small, targeted amounts of steam to kill cancer cells is a safe and effective treatment for prostate cancer.

[Cell Death & Disease] Researchers demonstrated that melanophilin (MLPH) promoted PDAC metastasis by inducing the regrowth of primary cilia. Clinically, high MLPH expression was positively correlated with metastasis and poor PDAC prognosis.

[Journal of Clinical Investigation] Scientists elucidated how BRCA1 associated protein 1 (BAP1) was involved in transcriptional regulation of MHC-II expression and how BAP1 impacted B cell lymphoma tumor growth via regulating tumor microenvironment and immune cell infiltration.

[Cell Stem Cell] Scientists used mouse totipotent blastomere-like cells (TBLCs) to develop spontaneous differentiation and blastoid formation systems, respectively. They found Wnt signaling enabled the rapid expansion of TBLCs and the optimization of their culture medium.

[Nature Protocols] Researchers introduced an ex vivo feeder-free culture method to differentiate gene-engineered hematopoietic stem and progenitor cells into allogeneic invariant natural killer T cells and their CAR-armed derivatives.

[Nature Communications] Investigators reported that islets of patients with type 1 diabetes (T1D) showed preferential HLA-B hyper-expression when compared with non-diabetic donors, and islet-infiltrating CD8+ T cells reactive to HLA-B-restricted granule peptides were found in T1D donors.

[Journal of Clinical Investigation] Researchers demonstrated that endothelial STING expression was critical for STING agonist–induced antitumor activity.

[Nucleic Acids Research] Scientists used cryoelectron microscopy to visualize the mechanism of cA6 biosynthesis by the Csm effector complex from Enterococcus italicus.

[Communications Biology] Investigators elucidated the molecular mechanism by which hsa_circ_0001599 worked in human dental pulp stem cells during odontogenic differentiation.

[Trends In Neurosciences] Scientists discuss and synthesize recent advances in understanding the diversity, circuit integration, and functional properties of somatostatin-expressing group of GABAergic neurons.

[Scientific Reports] Investigators set up a new P. aeruginosa infection model, using 2D upper airway nasal organoids that were derived from 3D organoids.

[Science Translational Medicine] Human and mouse intestinal organoids confirmed that optic atrophy 1 (OPA1) was required for epithelial barrier functions.