[Nature Communications] Researchers showed that the chromatin accessibility profiles of myelodysplastic syndrome stem cells more accurately reflect disease status than those of progenitor cells and reveal the process of stem cell alterations during disease progression.

[Cell Death & Disease] The authors discuss current evidence suggesting that the acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI) system can be targeted for the prevention or treatment of a wide range of liver diseases.

[Nature Communications] Researchers found that NIMA-related kinase 7 (NEK7), targeted to mitochondria by its signal peptides, binds to succinate dehydrogenase complex iron sulfur subunit B (SDHB), stabilizing the spatial conformation of complex II and promoting forward electron transport.

[Oncogenesis] Scientists demonstrated that ubiquitin specific peptidase 5 (USP5) expression is significantly elevated in HCC tissues. The overexpression of USP5 was closely associated with larger tumor sizes, more satellite nodules and tumor emboli, and predicted unfavorable clinical outcome in HCC patients as well.

[Cell Research] Through an integrative analysis of multi-omics data from 279 HCC patients, researchers demonstrated that aberrant splicing events occur at a > 59-fold higher frequency than somatic mutations and generate substantially more immunogenic peptides with broader patient applicability.

[Cell Death & Disease] Investigators examined the role of SVEP1 in intrahepatic cholangiocarcinoma. Downregulated SVEP1 expression promoted ICC cell proliferation, chemotactic migration, and invasion in vitro, as well as tumor growth and lung metastasis in vivo.

[Curtin University] Liver cancer patients may soon be able to check if their disease has returned with a simple blood test that detects tumor-specific DNA changes in the bloodstream, as part of a new Curtin University-led research project.

[Gut] Researchers screened biocompatible nanoparticles for anti-metabolic dysfunction-associated steatotic liver disease capacities in vitro by evaluating their regulatory effects on perilipin-2 (PLIN2), the key molecule in lipid droplet formation and stability.

[Journal of Clinical and Translational Hepatology] Targeting the UFMylation-sterol regulatory element-binding protein 1 (SREBP1) axis, particularly through fatostatin and lenvatinib combination therapy, represents a novel therapeutic strategy for HCC.

[Cancer Immunology Research] Using single-cell RNA-sequencing and flow cytometry in BRAFi + MEKi treated melanoma, researchers showed herein that isogenic Gsdme knockout tumors show decreased infiltration with T cells, natural killer cells, and regulatory T cells compared to control tumors.

[Clinical and Experimental Medicine] Investigators compared the number of CD4/CD25/FOXP3 T regulatory cells in the different forms of autoimmune thyroid diseases and in the normal population.

[JCI Insight] Analyzing two independent cohorts,researchers identified distinct immunological differences driven by three main lymphocyte populations. Lower frequencies of mucosa-associated invariant T cells and naïve CD8 T cells were observed in late-onset myasthenia, suggesting enhanced immune senescence.