Structural Definition of a Pan-Sarbecovirus Neutralizing Epitope on the Spike S2 Subunit

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Researchers showed that the neutralizing activity of CV3-25 was maintained against the Alpha, Delta, Gamma and Omicron variants of concern as well as a SARS-CoV-like bat coronavirus with zoonotic potential by binding to a conserved linear peptide in the stem-helix region.
[Communications Biology]

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