Tag results:
pAkt
Hepatic Cell News
Resveratrol Induces the Fasting State and Alters Circadian Metabolism in Hepatocytes
[Plant Foods For Human Nutrition] Investigators studied the metabolic effect of resveratrol around the circadian clock in order to determine more accurately the hepatic signaling pathways involved. AML-12 hepatocytes were treated with resveratrol and clock and metabolic markers were measured around the clock.
Prostate Cell News
The Androgen Receptor—lncRNASAT1-AKT-p15 Axis Mediates Androgen-Induced Cellular Senescence in Prostate Cancer Cells
[Oncogene] Investigators analyzed the underlying molecular pathway and revealed that supraphysiological androgen levels induced cellular senescence in both, castration-sensitive LNCaP and castration-resistant prostate cancer C4-2 cells through the cell cycle inhibitor p15INK4b and increased phosphorylation of AKT.
Intestinal Cell News
AHA1 Regulates Cell Migration and Invasion via the EMT Pathway in Colorectal Adenocarcinomas
[Scientific Reports] To investigate how AHA1 expression regulated the cancer cell progression and/or metastasis of human colorectal cancer (CRC), the expression levels of AHA1 and Hsp90 were examined in 105 CRC tissue samples and compared with those in paired normal tissue.
Extracellular Matrix News
A Liquid Culture Cancer Spheroid Model Reveals Low PI3K/Akt Pathway Activity and Low Adhesiveness to the Extracellular Matrix
[FEBS Journal] Scientists examined liquid culture cancer spheroids for the acquisition of apical‐basal polarity, sensitivity to an Akt inhibitor and interaction with extracellular matrix.
Pancreatic Cell News
Role of TGF-β in Pancreatic Ductal Adenocarcinoma Progression and PD-L1 Expression
[Cellular Oncology] Scientists investigated the expression of non-SMAD-transforming growth factor-beta (TGF-β) signaling proteins patient-derived tissues, cell lines and an immunocompetent mouse model.
Pancreatic Cell News
A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells
[Nutrition and Cancer] Scientists investigated whether fucoxanthinol (FxOH), induced apoptosis in human pancreatic cancer cells. FxOH significantly promoted the growth of human pancreatic cancer PANC-1 cells.