neural cells

[Glia] Scientists identified the underlying mechanism and showed that microglial morphology and functions were already impaired during glioma initiation stages.

[Molecular and Cellular Biochemistry] Scientists utilized bone morphogenetic protein (BMP) inhibitors DMH1, JL5, and Ym155 to examine the role of BMP signaling on the growth of glioblastomas.

[Cell Stem Cell] Researchers showed that viral delivery of GDNF to the striatum, in conjunction with homotopic transplantation of human PSC-derived midbrain dopamine (mDA) neurons, recapitulated brain-wide mDA target innervation.

[Nature Aging] To elucidate the polygenic architecture of Alzheimer’s disease (AD) phenotypes at a cellular level, the authors established iPSCs from 102 patients with AD, differentiated them into cortical neurons and conducted a genome-wide analysis of the neuronal production of amyloid β (Aβ).

[Nature Metabolism] The authors showed that membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) was an endogenous negative regulator of GDNF-family receptor a-like (GFRAL) in the context of obesity.

[Cell Reports] Researchers showed that stimulation of neurons caused condensation of large chromatin domains. This phenomenon can be observed in vitro in cultured rat hippocampal neurons as well as in vivo in the amygdala and hippocampal neurons.