Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Amplified Dosage of the NKX2-1 Lineage Transcription Factor Controls Its Oncogenic Role in Lung Adenocarcinoma
[Molecular Cell] Investigators found that the most significant focal amplification event in lung adenocarcinoma (LUAD) targeted a lineage “super-enhancer” near the NKX2-1 lineage transcription factor.
Lactylation Increases the Stability of RBM15 to Drive M6a Modification in Non-Small-Cell Lung Cancer Cells
[FASEB Journal] Scientists observed that L-lactate upregulated RNA-binding protein 15 (RBM15) protein levels in non-small-cell lung cancer cell lines A549 and H23 in a time- and dosage-dependent manner.
UK Medicines and Healthcare Products Regulatory Agency Confirms Acceptance of Marketing Authorization Application for Proposed Biosimilar to Xolair® (omalizumab)
[Advanz Pharma] Alvotech, Kashiv Biosciences LLC, and ADVANZ PHARMA, announced that the UK Medicines and Healthcare Products Regulatory Agency has accepted a marketing application for AVT23, a proposed biosimilar to Xolair®.
NOTCH Pathway Was Involved in Kaempferol 3-O-Gentiobioside Attenuated Airway Inflammation and Mucus Hypersecretion
[Scientific Reports] Researchers evaluated the impact of Kaempferol 3-O-gentiobioside on inflammatory cytokine secretion and mucus overproduction in IL-13-stimulated airway epithelial cells and ovalbumin-induced allergic asthma mouse models.
Microplastics Exacerbate Ferroptosis via Mitochondrial Reactive Oxygen Species-Mediated Autophagy in Chronic Obstructive Pulmonary Disease
[Autophagy] Researchers demonstrated that microplastics intensified inflammation in COPD by enhancing autophagy-dependent ferroptosis in vitro and in vivo.
Induction of Necroptosis in Lung Adenocarcinoma by mir‑10b‑5p through Modulation of the PKP3/RIPK3/MLKL Cascade
[Oncology Reports] Scientists elucidated the role and underlying mechanisms of miR‑10b‑5p in regulating necroptosis in the context of LUAD.
ZNF768 Loss Amplifies p53 Action and Reduces Lung Tumorigenesis in Mice
[Oncogene] Investigators reported the generation and characterization of a ZNF768 null mouse model. ZNF768 null mice were viable but showed a growth defect early in life.
The NcRNA/Wnt Axis in Lung Cancer: Oncogenic Mechanisms, Remarkable Indicators, and Therapeutic Targets
[Journal of Translational Medicine] The authors comprehensively review the regulatory mechanisms related to the functions of ncRNAs and the Wnt/β-catenin pathway in lung cancer.
Novel Selective Strategies Targeting the BCL-2 Family to Enhance Clinical Efficacy in ALK-Rearranged Non-Small Cell Lung Cancer
[Cell Death & Disease] Investigators found that dynamic BH3 profiling presented an excellent predictive capacity to anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors, that would facilitate their use in a clinical setting and complementing the readout of standard diagnostic assays.
RNA m7G Methylation Regulators and Targets Significantly Contribute to Chronic Obstructive Pulmonary Disease
[Scientific Reports] The combined roles of m7G methylation regulators were explored in COPD for the first time by integrated bioinformatic methods.
The Role of HDAC3 in Pulmonary Diseases
[Lung] Investigators systematically examine the structural and functional features of histone deacetylase 3 (HDAC3) and discuss its multifaceted contributions to pulmonary pathologies, including lung injury, pulmonary fibrosis, and lung cancer.
SMSbiotech Receives Green Light for Phase I Clinical Trial in Australia, Targeting COPD
[SMSbiotech ] SMSbiotech has announced a significant milestone in its pursuit of its regenerative medicine technology, securing approval to commence a Phase I clinical trial in Australia.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
