Prostate Cell News
Prostate Cell News is an online resource summarizing the latest prostate cell research.
FDA Approves New Prostate Cancer Imaging Agent Gozellix®
[Telix Pharmaceuticals Limited] Telix announce that the US FDA has approved its New Drug Application for Gozellix®, Telix’s next-generation PSMA-PET imaging agent for prostate cancer.
Small-Molecule RNA Therapeutics to Target Prostate Cancer
[Cancer Cell] To understand whether targeting RNA structure using small molecules in the most lethal form of prostate cancer, castration-resistant prostate cancer, the authors used a clinical small molecule, zotatifin, that targeted the RNA helicase and translation factor eukaryotic initiation factor 4A.
Lipid-Metabolism-Focused CRISPR Screens Identify Enzymes of the Mevalonate Pathway As Essential for Prostate Cancer Growth
[Cell Reports] Researchers employed a CRISPR-Cas9 screen using a custom human lipid metabolism knockout library to identify essential genes for prostate cancer survival.
Prostate Cancer: Genetics in Practice Now and in the Future
[Hereditary Cancer in Clinical Practice] The authors write a mini review of how the genetics of prostate cancer can impact on screening and early detection of the disease and the treatment and management of the disease when diagnosed.
ETV5 Reduces Androgen Receptor Expression and Induces Neural Stem-Like Properties during Neuroendocrine Prostate Cancer Development
[Proceedings of The National Academy of Sciences of The United States of America] The authors explored the role of E26 transformation-specific variant 5 (ETV5) in neuroendocrine prostate cancer development. Analysis of multiple prostate cancer datasets revealed that NEPC was characterized by significantly elevated ETV5 expression compared to other subtypes.
The Landscape of N6-methyladenosine in Localized Primary Prostate Cancer
[Nature Genetics] The authors characterized the N6-methyladenosine landscape of 162 localized prostate tumors with matched DNA, RNA, and protein profiling.
The Olfactory Receptor OR51E2 Regulates Prostate Cancer Aggressiveness and Modulates STAT3 in Prostate Cancer Cells and in Xenograft Tumors
[BMC Cancer] Researchers investigated the physiological effects of OR51E2 through CRISPR-Cas9-induced monoclonal OR51E2 knockout.
Inhibition of Steroidogenesis in Prostate Cancer Cells by Both a Natural and Another Synthetic Steroid
[Drug Development Research] Scientists investigated the potential of β-sitosterol and the synthetic derivative 2 as potent inhibitors of androgen synthesis, a critical process for the growth and survival of prostate tumor LNCaP cells.
Blood-Based Detection of MMP11 As a Marker of Prostate Cancer Progression Regulated by the ALDH1A1-TGF-β1 Signaling Mechanism
[Journal of Experimental & Clinical Cancer Research] Genetic silencing, gene overexpression, or treatment with different concentrations of the retinoic acid isomers, which were the products of aldehyde dehydrogenase (ALDH) catalytic activity, were used to modulate the interplay between retinoic acid receptors and androgen receptor.
The Combination of Poly(ADP-Ribose) Polymerase Inhibitor and Statin Inhibits the Proliferation of Human Castration-Resistant and Taxane-Resistant Prostate Cancer Cells In Vitro and In Vivo
[BMC Cancer] PC-3, LNCaP, and 22Rv1 human prostate cancer cell lines were used to develop androgen-independent LNCaP cells. mRNA and protein expression levels were evaluated by quantitative real-time polymerase chain reaction and western blot analysis, respectively.
Prevalence of Mismatch Repair Deficiency in Primary Prostate Cancer in a Large Prospective Cohort
[Clinical Cancer Research] This study included 1,016 men diagnosed with primary prostate cancer during prospective follow-up of the Health Professionals Follow-up Study and Physicians’ Health Study.
Single-Cell and Spatial Transcriptomics Reveal a Tumor-Associated Macrophage Subpopulation That Mediates Prostate Cancer Progression and Metastasis
[Molecular Cancer Research] The authors integrated parallel datasets from single-cell RNA-sequencing, spatial transcriptomics, and multiplex immunofluorescence to reveal the dynamics of tumor-associated macrophages in primary and metastatic prostate cancer.
Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.
