Pancreatic Cell News
Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Identification of FLVCR1 As the Iron Metabolism-Related Gene of Statin-Associated Diabetes
[Acta Diabetologica] Scientists identified the co-expression gene modules and the iron metabolism-related gene linking statin administration and diabetes.
METTL3-Dependent m6a Methylation of circCEACAM5 Fuels Pancreatic Cancer Progression through DKC1 Activation
[Cellular and Molecular Life Sciences] Investigators examined the role of circCEACAM5 in pancreatic cancer, particularly its regulation by METTL3-mediated N6-methyladenosine (m6A) methylation and interaction with effectors such as dyskeratosis congenita 1 (DKC1).
Curcumin Ameliorates Cerulein‑Induced Chronic Pancreatitis through Nrf‑2/HO‑1 Signaling
[Molecular Medicine Reports] Researchers investigated whether curcumin improved cerulein‑induced chronic pancreatitis fibrosis in a mouse model and pancreatic stellate cells.
The Expression Order Determines the Pioneer Functions of NGN3 and NEUROD1 in Pancreatic Endocrine Differentiation
[Science Advances] Researchers investigated how the sequential expression of neurogenin 3 (NGN3) and NEUROD1 affects their pioneering functions during pancreatic endocrine differentiation.
GLP-1 Receptor Agonists Causing Euglycemic Ketoacidosis in Patients without Diabetes: A Brief Review
[International Journal of Obesity] The authors discuss the known literature on euglycemic ketoacidosis associated with GLP-1RA and the risk factors for the condition.
Neoadjuvant BMS-813160, Nivolumab, Gemcitabine, and Nab-Paclitaxel for Patients with Pancreatic Cancer
[Clinical Cancer Research] Scientists conducted a Phase I/II single institution study combining chemotherapy gemcitabine and nab-paclitaxel, CCR2/5 inhibitor BMS-813160, and nivolumab for four 28-day cycles for patients with borderline resectable or locally advanced PDAC.
Genetic Protection from Type 1 Diabetes Resulting from Accelerated Insulin mRNA Decay
[Cell] Investigators discovered that the inositol-requiring enzyme 1α (IRE1α) digestion motif was present in insulin mRNA carrying SNP rs3842752. This SNP in the 3′ untranslated region of insulin gene associated with protection from T1D.
Septin5 Deletion Enhances β-cell Exocytosis by Releasing Microtubule-Tethered Insulin Granules onto Plasma Membrane
[Nature Communications] Scientists reported that Septin5 was abundant in rodent and human β-cells, deletion of which dramatically enhanced biphasic glucose-stimulated insulin secretion, including in type 2 diabetes.
Investigating Synthetic Lethality and PARP Inhibitor Resistance in Pancreatic Cancer through Enantiomer Differential Activity
[Cell Death Discovery] Through multiple, integrated orthogonal biological approaches in different 2D and 3D PDAC cultures, researchers characterized RS-35d enantiomers, in terms of mode of action and single contributions.
PLXDC1+ Tumor-Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma
[Advanced Science] Researchers combined RNA sequencing and assay for transposase-accessible chromatin using sequencing on sorted pancreatic stellate cells from adjacent normal and PDAC tissues to investigate their transcriptional and epigenetic activation.
NIH Cancels Funding for Landmark Diabetes Study at a Time of Focus on Chronic Disease
[STAT] The Trump administration has canceled funding for an ongoing 30-year, nationwide study tracking patients with prediabetes and diabetes, researchers said, at a time when top officials have emphasized their determination to curb the incidence of such chronic conditions.
PEP-Therapy Receives FDA Orphan Drug Designation for PEP-010 for Treatment of Pancreatic Cancer
[PEP-Therapy (GlobeNewswire)] PEP-Therapy announced that the US FDA has granted Orphan Drug designation to its flagship product, PEP-010, for the treatment of pancreatic cancer.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
