Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Organoid Models of Breast Cancer in Precision Medicine and Translational Research
[Molecular Biology Reports] Investigators evalurate a variety of breast cancer (BC) studies performed on organoid culture systems. Additionally, they report the potential of using organoid models in BC translational research, especially in immunotherapy, drug screening, and precision medicine.
Accelerated Production of Human Epithelial Organoids in a Miniaturized Spinning Bioreactor
[Cell Reports Methods] The authors developed a miniaturized spinning bioreactor, RPMotion, specifically optimized for accelerated and cost-effective culture of epithelial organoids under homogeneous conditions.
The Glucocorticoid Receptor Potentiates Aldosterone-Induced Transcription by the Mineralocorticoid Receptor
[Proceedings of The National Academy of Sciences of The United States of America] Researchers analyzed the impact of glucocorticoid receptor coexpression on mineralocorticoid receptor genome-wide transcriptional responses and chromatin binding upon activation by aldosterone and glucocorticoids, both physiological ligands of this receptor.
Adenoviral Delivery of the CIITA Transgene Induces T Cell-Mediated Killing in Glioblastoma Organoids
[Molecular Oncology] The authors adopted a cancer gene therapy approach to induce -cell-mediated killing of the tumor through increased activation of the immune system.
Spatial Transcriptomics Reveals Molecular Cues Underlying the Site Specificity of the Adult Mouse Oral Mucosa and Its Stem Cell Niches
[Stem Cell Reports] The authors performed spatial transcriptomics on the tongue, cheeks, and palate of the adult mouse to understand the cues that maintain the oral mucosal sites.
Physiological Modeling of the Vascularized Human Lung Organoid
[American Journal of Respiratory Cell and Molecular Biology] Investigators described a method for vessel infiltration of human lung organoid (hLO) in which they determined differences of these hLOs with standard avascular hLOs.
Lamination-Based Organoid Spatially Resolved Transcriptomics Technique for Primary Lung and Liver Organoid Characterization
[Proceedings of The National Academy of Sciences of The United States of America] Researchers presented a technique, lamination-based organoid spatially resolved transcriptomics, for organoid-spatially resolved transcriptomics based on organoid lamination.
Organoids and Organoid Extracellular Vesicles-Based Disease Treatment Strategies
[Journal of Nanobiotechnology] Investigators provide an overview of the fundamental biological principles of organoids and organoid-derived extracellular vesicles, and discuss their current applications in disease treatment.
Advancing Cancer Research through Organoid Technology
[Journal of Translational Medicine] The authors explore the application of organoid technology for more precise tumor simulations and its specific contributions to cancer research advancements.
Generating Tooth Organoids Using Defined Bioorthogonally Cross-Linked Hydrogels
[ACS Macro Letters] Scientists used bioorthogonally cross-linked hydrogels as defined 3D matrixes for tooth developmental engineering, and highlighted how their properties played a pivotal role in enabling 3D tooth organoid formation in vitro.
The Culture and Application of Circulating Tumor Cell-Derived Organoids
[Trends in Cell Biology] The authors summarize the origin, isolation, enrichment, culture, validation, and clinical application of circulating tumor cells (CTCs) and CTC-derived organoidss.
Human Immune Organoids to Decode B Cell Response in Healthy Donors and Patients with Lymphoma
[Nature Materials] The authors developed synthetic hydrogels mimicking the lymphoid tissue microenvironment, enabling human germinal centers from tonsils, and peripheral blood mononuclear cell-derived B cells.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
