Targeting McOln1/TRPML1 Channels to Protect against Ischemia-Reperfusion Injury by Restoring the Inhibited Autophagic Flux in Cardiomyocytes

Investigators revealed that MCOLN1/TRPML1, a lysosomal cationic channel, directly contributed to the inhibition of autophagic flux in cardiomyocytes post ischemia-reperfusion.