Cancer Stem Cells-Derived Exosomal TSPAN8 Enhances Non-Stem Cancer Cells Stemness and Promotes Malignant Progression in PDAC

Investigators employed single-cell RNA sequencing and exosomal profiling, identifying TSPAN8-enriched exosomes secreted by CSC, which were associated with poor survival rates in pancreatic ductal adenocarcinoma patients.