Intestinal Secretory Differentiation Reflects Niche-Driven Phenotypic and Epigenetic Plasticity of a Common Signal-Responsive Terminal Cell

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Based on morphology, location, and canonical markers, goblet and Paneth cells were considered distinct secretory types. The authors reported high overlap in their transcripts and sites of accessible chromatin, in marked contrast to those of their enteroendocrine or tuft cell siblings.
[Cell Stem Cell]
AbstractGraphical Abstract